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Submit ReviewPentamidine isethionate
Description: NMDA antagonist: antimicrobial
Chemical Name: 4,4'-(Pentamethylenedioxy)dibenzamidine bis-2-hydroxyethanesulfonate salt
Purity: ≥99% (HPLC)
Biological Activity
Antimicrobial. Neuroprotective; inhibits constitutive nitric oxide synthase in the brain and acts as a NMDA glutamate receptor antagonist.
Technical Data
| M. Wt | 592.68 |
| Formula | C19H24N4O2.2C2H6O4S |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 140-64-7 |
| PubChem ID | 8813 |
| InChI Key | YBVNFKZSMZGRAD-UHFFFAOYSA-N |
| Smiles | NC(C1=CC=C(OCCCCCOC2=CC=C(C(N)=N)C=C2)C=C1)=N.OCCS(=O)(O)=O.OCCS(=O)(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 59.27 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 592.68. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.69 mL | 8.44 mL | 16.87 mL |
| 5 mM | 0.34 mL | 1.69 mL | 3.37 mL |
| 10 mM | 0.17 mL | 0.84 mL | 1.69 mL |
| 50 mM | 0.03 mL | 0.17 mL | 0.34 mL |
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References
References are publications that support the biological activity of the product.
Reynolds and Aizeman (1992) Pentamidine is an N-MthD.-aspartate receptor antagonist and is neuroprotective in vitro. J.Neurosci. 12 970 PMID: 1532027
Kitamura et al (1995) Inhibition of constitutive nitric oxide synthase in the brain by pentamidine, a calmodulin antagonist. Eur.J.Pharmacol. 289 299 PMID: 7542607
If you know of a relevant reference for Pentamidine isethionate, please let us know.
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Keywords: Pentamidine isethionate, Pentamidine isethionate supplier, Antimicrobial, inhibits, inhibitors, constitutive, nNOS, NMDA, antagonist, receptors, Nitric, Oxide, Signaling, Signalling, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, Neuronal, oxide, Synthases, Miscellaneous, Compounds, 3277, Tocris Bioscience
1 Citation for Pentamidine isethionate
Citations are publications that use Tocris products. Selected citations for Pentamidine isethionate include:
Capoccia et al (2015) S100B-p53 disengagement by pentam. promotes apoptosis and inhibits cellular migration via aquaporin-4 and metalloproteinase-2 inhibition in C6 glioma cells. Oncol Lett 9 2864 PMID: 26137161
Do you know of a great paper that uses Pentamidine isethionate from Tocris? Please let us know.
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