Pentamidine isethionate

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Cat.No. 3277 - Pentamidine isethionate | C19H24N4O2.2C2H6O4S | CAS No. 140-64-7
Description: Antimicrobial that antagonizes NMDA receptors
Chemical Name: 4,4'-(Pentamethylenedioxy)dibenzamidine bis-2-hydroxyethanesulfonate salt
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Antimicrobial. Neuroprotective; inhibits constitutive nitric oxide synthase in the brain and acts as a NMDA glutamate receptor antagonist.

Technical Data

M. Wt 592.68
Formula C19H24N4O2.2C2H6O4S
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 140-64-7
PubChem ID 8813
InChI Key YBVNFKZSMZGRAD-UHFFFAOYSA-N
Smiles NC(C1=CC=C(OCCCCCOC2=CC=C(C(N)=N)C=C2)C=C1)=N.OCCS(=O)(O)=O.OCCS(=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 59.27 100

Preparing Stock Solutions

The following data is based on the product molecular weight 592.68. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.69 mL 8.44 mL 16.87 mL
5 mM 0.34 mL 1.69 mL 3.37 mL
10 mM 0.17 mL 0.84 mL 1.69 mL
50 mM 0.03 mL 0.17 mL 0.34 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Reynolds and Aizeman (1992) Pentamidine is an N-methyl-D-aspartate receptor antagonist and is neuroprotective in vitro. J.Neurosci. 12 970 PMID: 1532027

Kitamura et al (1995) Inhibition of constitutive nitric oxide synthase in the brain by pentamidine, a calmodulin antagonist. Eur.J.Pharmacol. 289 299 PMID: 7542607


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View Related Products by Product Action

View all NMDA Receptor Antagonists

Keywords: Antimicrobial inhibits inhibitors constitutive nNOS NMDA antagonist receptors Nitric Oxide Signaling Signalling Glutamate Receptors N-Methyl-D-Aspartate iGluR Ionotropic Neuronal oxide Synthases NMDA Receptors

1 Citation for Pentamidine isethionate

Citations are publications that use Tocris products. Selected citations for Pentamidine isethionate include:

Capoccia et al (2015) S100B-p53 disengagement by pentamidine promotes apoptosis and inhibits cellular migration via aquaporin-4 and metalloproteinase-2 inhibition in C6 glioma cells. Oncol Lett 9 2864 PMID: 26137161


Do you know of a great paper that uses Pentamidine isethionate from Tocris? If so please let us know.

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