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Submit ReviewPentamidine isethionate
Discontinued Product
Pentamidine isethionate (Cat. No. 3277) has been withdrawn from sale for commercial reasons.
Description: NMDA antagonist: antimicrobial
Chemical Name: 4,4'-(Pentamethylenedioxy)dibenzamidine bis-2-hydroxyethanesulfonate salt
Purity: ≥99% (HPLC)
Biological Activity for Pentamidine isethionate
Pentamidine isethionate is an antimicrobial. Neuroprotective; inhibits constitutive nitric oxide synthase in the brain and acts as a NMDA glutamate receptor antagonist.
Technical Data for Pentamidine isethionate
| M. Wt | 592.68 |
| Formula | C19H24N4O2.2C2H6O4S |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 140-64-7 |
| PubChem ID | 8813 |
| InChI Key | YBVNFKZSMZGRAD-UHFFFAOYSA-N |
| Smiles | NC(C1=CC=C(OCCCCCOC2=CC=C(C(N)=N)C=C2)C=C1)=N.OCCS(=O)(O)=O.OCCS(=O)(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Pentamidine isethionate
References for Pentamidine isethionate
References are publications that support the biological activity of the product.
Reynolds and Aizeman (1992) Pentamidine is an N-MthD.-aspartate receptor antagonist and is neuroprotective in vitro. J.Neurosci. 12 970 PMID: 1532027
Kitamura et al (1995) Inhibition of constitutive nitric oxide synthase in the brain by pentamidine, a calmodulin antagonist. Eur.J.Pharmacol. 289 299 PMID: 7542607
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Keywords: Pentamidine isethionate, Pentamidine isethionate supplier, Antimicrobial, inhibits, inhibitors, constitutive, nNOS, NMDA, antagonist, receptors, Nitric, Oxide, Signaling, Signalling, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, Neuronal, oxide, Synthases, Miscellaneous, Compounds, 3277, Tocris Bioscience
1 Citation for Pentamidine isethionate
Citations are publications that use Tocris products. Selected citations for Pentamidine isethionate include:
Capoccia et al (2015) S100B-p53 disengagement by pentam. promotes apoptosis and inhibits cellular migration via aquaporin-4 and metalloproteinase-2 inhibition in C6 glioma cells. Oncol Lett 9 2864 PMID: 26137161
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