Pricing Availability   Qty
Description: Potent and irreversible EGFR inhibitor; orally bioavailable
Alternative Names: EKB-569
Chemical Name: (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide
Purity: ≥97% (HPLC)
Literature (1)

Biological Activity for Pelitinib

Pelitinib is a potent irreversible EGFR inhibitor (IC50 = 20-80 nM). Selective for EGFR over Src, MEK/ERK, erbB2, Raf, c-Met and Cdk4 (IC50 values are 282, 800, 1255, 3353, 4100 and >20,000). Inhibits the growth of tumors overexpressing EGFR in vivo. Orally bioavailable.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc

Compound Libraries for Pelitinib

Pelitinib is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Pelitinib

M. Wt 467.92
Formula C24H23ClFN5O2
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 257933-82-7
PubChem ID 6445562
Smiles O=C(/C=C/CN(C)C)NC1=C(OCC)C=C(N=CC(C#N)=C2NC3=CC=C(F)C(Cl)=C3)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Pelitinib

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 23.4 50

Preparing Stock Solutions for Pelitinib

The following data is based on the product molecular weight 467.92. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.27 mL 21.37 mL 42.74 mL
2.5 mM 0.85 mL 4.27 mL 8.55 mL
5 mM 0.43 mL 2.14 mL 4.27 mL
25 mM 0.09 mL 0.43 mL 0.85 mL

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Citations for Pelitinib

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Angiogenesis in Cancer Poster

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.