PD 173212

Pricing Availability Delivery Time Qty
Cat.No. 3552 - PD 173212 | C38H53N3O3 | CAS No. 217171-01-2
Description: Potent N-type Ca2+ channel blocker
Chemical Name: N-[[4-(1,1-Dimethylethyl)phenyl]methyl-N-methyl-L-leucyl-N-(1,1-dimethylethyl)-O-phenylmethyl)-L-tyrosinamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent N-type voltage-gated calcium channel blocker (IC50 = 36 nM). Displays selectivity over K+, Na+ and L-type Ca2+ channels. Prevents tonic seizures in the audiogenic seizure model in vivo.

Compound Libraries

PD 173212 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 599.85
Formula C38H53N3O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 217171-01-2
PubChem ID 9916734
InChI Key GCDHMGROXQUFNR-HEVIKAOCSA-N
Smiles CC(C)(C)C1=CC=C(CN(C)[C@H](C(N[C@H]([C@](NC(C)(C)C)=O)CC2=CC=C(OCC3=CC=CC=C3)C=C2)=O)CC(C)C)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 59.98 100
ethanol 59.98 100

Preparing Stock Solutions

The following data is based on the product molecular weight 599.85. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.67 mL 8.34 mL 16.67 mL
5 mM 0.33 mL 1.67 mL 3.33 mL
10 mM 0.17 mL 0.83 mL 1.67 mL
50 mM 0.03 mL 0.17 mL 0.33 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Hu et al (1999) Structure-activity relationships of N-methyl-N-aralkyl-peptidylamines as novel N-type calcium channel blockers. Bioorg.Med.Chem.Letts. 9 2151 PMID:


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View Related Products by Product Action

View all Voltage-gated Calcium Channel (CaV) Blockers

Keywords: Potent N-type Ca2+ channel blockers Calcium CaV Channels voltage-gated voltage-dependent PD173212 Voltage-gated Calcium Channels

Citations for PD 173212

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Literature in this Area

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Pathways for PD 173212

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