PD 161570

Pricing Availability Delivery Time Qty
Cat.No. 3724 - PD 161570 | C26H35Cl2N7O | CAS No. 192705-80-9
Description: Selective FGFR inhibitor
Chemical Name: N-[6-(2,6-Dichlorophenyl)-2-[[4-(diethylamino)butyl]amino]pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Selective FGFR inhibitor (IC50 values are 40, 262 and 3700 nM for FGFR, PDGFR and EGFR respectively). Inhibits FGFR receptor phosphorylation (IC50 = 622 nM) and growth of A121 cells in vitro.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries

PD 161570 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 532.51
Formula C26H35Cl2N7O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 192705-80-9
PubChem ID 5328135
InChI Key MKVMEJKNLUWFSQ-UHFFFAOYSA-N
Smiles ClC1=CC=CC(Cl)=C1C3=CC2=CN=C(NCCCCN(CC)CC)N=C2N=C3NC(NC(C)(C)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 53.25 100
ethanol 53.25 100

Preparing Stock Solutions

The following data is based on the product molecular weight 532.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.88 mL 9.39 mL 18.78 mL
5 mM 0.38 mL 1.88 mL 3.76 mL
10 mM 0.19 mL 0.94 mL 1.88 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Hamby et al (1997) Structure-activity relationships for a novel series of pyrido[2,3-d]pyrimidine tyrosine kinase inhibitors. J.Med.Chem. 40 2296 PMID: 9240345

Batley et al (1998) Inhibition of FGF-1 receptor tyrosine kinase activity by PD 161570, a new protein-tyrosine kinase inhibitor. Life Sci. 62 143 PMID: 9488112

Stevens et al (2003) Thyroid hormone activates fibroblast growth factor receptor-1 in bone. Mol.Endocrinology 17 1751 PMID:


If you know of a relevant reference for PD 161570, please let us know.

View Related Products by Product Action

View all FGFR Inhibitors

Keywords: PD161570 selective FGFR inhibitors inhibits fibroblast growth factors Pfizer FGFR

1 Citation for PD 161570

Citations are publications that use Tocris products. Selected citations for PD 161570 include:

Rodríguez et al (2012) Modulation of pluripotency in the porcine embryo and iPS cells. J Exp Bot 7 e49079 PMID: 23145076


Do you know of a great paper that uses PD 161570 from Tocris? If so please let us know.

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Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

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Stem Cells

Stem Cells Scientific Review

Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

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Pathways for PD 161570

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