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Submit ReviewPD 150606
Description: Cell permeable calpain inhibitor
Chemical Name: (Z)-3-(4-Iodophenyl)-2-mercapto-2-propenoic acid
Purity: ≥95% (HPLC)
Biological Activity for PD 150606
PD 150606 is a selective, cell-permeable non-peptide calpain inhibitor (Ki values for ν and m-calpains are 0.21 and 0.37 μM respectively). Targets the calcium binding sites of calpain. Demonstrates high specificity for calpains relative to other proteases, and is a non-competitive inhibitor with respect to the substrate.
Technical Data for PD 150606
| M. Wt | 306.12 |
| Formula | C9H7IO2S |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 179528-45-1 |
| PubChem ID | 9839500 |
| InChI Key | DJCVSFWGKYHMKH-YVMONPNESA-N |
| Smiles | IC1=CC=C(/C=C(C(O)=O)\S)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for PD 150606
References for PD 150606
References are publications that support the biological activity of the product.
Squier et al (1999) Calpain and calpastatin regulate neutrophil apoptosis. J.Cell Physiol. 178 311 PMID: 9989777
Wang et al (1996) An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective. Proc.Natl.Acad.Sci.U.S.A. 93 6687 PMID: 8692879
Waters et al (1997) Calpains mediate calcium chloride influx during the late phase of cell injury. J.Pharmacol.Exp.Ther. 283 1177 PMID: 9399991
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Keywords: PD 150606, PD 150606 supplier, PD150606, calpain, inhibitors, inhibits, selective, Ca2+Sensitive, Protease, modulators, Calcium-Sensitive, Ca2+, Signaling, Signalling, Proteinases, Proteases, Calpains, 1269, Tocris Bioscience
6 Citations for PD 150606
Citations are publications that use Tocris products. Selected citations for PD 150606 include:
Chang et al (2017) Paxillin facilitates timely neurite initiation on soft-substrate environments by interacting with the endocytic machinery. Elife 6 PMID: 29271742
Pradhan et al (2017) The C-Box Region of MAF1 Regulates Transcriptional Activity and Protein Stability. J Mol Biol 429 192 PMID: 27986570
Getz et al (2016) Two proteolytic fragments of menin coordinate the nuclear transcription and postsynaptic clustering of neurotransmitter receptors during synaptogenesis between Lymnaea neurons. Sci Rep 6 31779 PMID: 27538741
Chamma et al (2013) Activity-dependent regulation of the K/Cl transporter KCC2 membrane diffusion, clustering, and function in hippocampal neurons. J Neurosci 33 15488 PMID: 24068817
Bill et al (2015) ANO1 interacts with EGFR and correlates with sensitivity to EGFR-targeting therapy in head and neck cancer. PLoS One 6 9173 PMID: 25823819
Alvarez-Arce (2017) Thrombin-induced calpain activation promotes protease-activated receptor 1 internalization. Int J Cell Biol 2017 1908310 PMID: 29250115
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Cell Cycle and DNA Damage Research Product Guide
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- Cell Cycle and Mitosis
- DNA Damage Repair
- Targeted Protein Degradation
- Ubiquitin Proteasome Pathway
- Chemotherapy Targets
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