Selective, cell-permeable non-peptide calpain inhibitor (Ki values for ν and m-calpains are 0.21 and 0.37 μM respectively). Targets the calcium binding sites of calpain. Demonstrates high specificity for calpains relative to other proteases, and is a non-competitive inhibitor with respect to the substrate.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 306.12. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.27 mL||16.33 mL||32.67 mL|
|5 mM||0.65 mL||3.27 mL||6.53 mL|
|10 mM||0.33 mL||1.63 mL||3.27 mL|
|50 mM||0.07 mL||0.33 mL||0.65 mL|
References are publications that support the products' biological activity.
Squier et al (1999) Calpain and calpastatin regulate neutrophil apoptosis. J.Cell Physiol. 178 311 PMID: 9989777
Wang et al (1996) An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective. Proc.Natl.Acad.Sci.U.S.A. 93 6687 PMID: 8692879
Waters et al (1997) Calpains mediate calcium chloride influx during the late phase of cell injury. J.Pharmacol.Exp.Ther. 283 1177 PMID: 9399991
If you know of a relevant reference for PD 150606, please let us know.
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Keywords: PD 150606, supplier, PD150606, calpain, inhibitors, inhibits, selective, Ca2+Sensitive, Protease, modulators, Calcium-Sensitive, Ca2+, Signaling, Signalling, Proteinases, Proteases, Calcium-Sensitive, Proteases, Calpains, Calpains, Tocris Bioscience
5 Citations for PD 150606
Citations are publications that use Tocris products. Selected citations for PD 150606 include:
Pradhan et al (2017) The C-Box Region of MAF1 Regulates Transcriptional Activity and Protein Stability. J Mol Biol 429 192 PMID: 27986570
Alvarez-Arce (2017) Thrombin-induced calpain activation promotes protease-activated receptor 1 internalization. Int J Cell Biol 2017 1908310 PMID: 29250115
Bill et al (2015) ANO1 interacts with EGFR and correlates with sensitivity to EGFR-targeting therapy in head and neck cancer. PLoS One 6 9173 PMID: 25823819
Chamma et al (2013) Activity-dependent regulation of the K/Cl transporter KCC2 membrane diffusion, clustering, and function in hippocampal neurons. J Neurosci 33 15488 PMID: 24068817
Getz et al (2016) Two proteolytic fragments of menin coordinate the nuclear transcription and postsynaptic clustering of neurotransmitter receptors during synaptogenesis between Lymnaea neurons. Sci Rep 6 31779 PMID: 27538741
Do you know of a great paper that uses PD 150606 from Tocris? If so please let us know.
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