PD 150606

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Cat.No. 1269 - PD 150606 | C9H7IO2S | CAS No. 179528-45-1
Description: Cell permeable calpain inhibitor
Chemical Name: (Z)-3-(4-Iodophenyl)-2-mercapto-2-propenoic acid
Purity: ≥95% (HPLC)
Datasheet
Citations (1)
Pathways

Biological Activity

Selective, cell-permeable non-peptide calpain inhibitor (Ki values for ν and m-calpains are 0.21 and 0.37 μM respectively). Targets the calcium binding sites of calpain. Demonstrates high specificity for calpains relative to other proteases, and is a non-competitive inhibitor with respect to the substrate.

Technical Data

M. Wt 306.12
Formula C9H7IO2S
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 179528-45-1
PubChem ID 9839500
InChI Key DJCVSFWGKYHMKH-YVMONPNESA-N
Smiles IC1=CC=C(/C=C(C(O)=O)\S)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.61 100
ethanol 15.31 50

Preparing Stock Solutions

The following data is based on the product molecular weight 306.12. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.27 mL 16.33 mL 32.67 mL
5 mM 0.65 mL 3.27 mL 6.53 mL
10 mM 0.33 mL 1.63 mL 3.27 mL
50 mM 0.07 mL 0.33 mL 0.65 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Squier et al (1999) Calpain and calpastatin regulate neutrophil apoptosis. J.Cell Physiol. 178 311 PMID: 9989777

Wang et al (1996) An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective. Proc.Natl.Acad.Sci.U.S.A. 93 6687 PMID: 8692879

Waters et al (1997) Calpains mediate calcium chloride influx during the late phase of cell injury. J.Pharmacol.Exp.Ther. 283 1177 PMID: 9399991


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1 Citation for PD 150606

Citations are publications that use Tocris products. Selected citations for PD 150606 include:

Bill et al (2015) ANO1 interacts with EGFR and correlates with sensitivity to EGFR-targeting therapy in head and neck cancer. PLoS One 6 9173 PMID: 25823819


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Pathways for PD 150606

Apoptosis

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.