PD 144418 oxalate

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Cat.No. 2606 - PD 144418 oxalate | C18H22N2O.C2H2O4 | CAS No. 1794760-28-3
Description: High affinity, selective σ1 ligand
Chemical Name: 1,2,3,6-Tetrahydro-5-[3-(4-methylphenyl)-5-isoxazolyl]-1-propylpyridine oxalate
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (1)

Biological Activity

High affinity, selective σ1 ligand (Ki values are 0.08 and 1377 nM for σ1 and σ2 respectively). Displays no significant activity at a wide range of other receptors, ion channels and enzymes. Antagonizes mescaline-induced scratching in mice following i.p. administration. Also attenuates cocaine-induced hyperactivity in mice.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries

PD 144418 oxalate is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 372.42
Formula C18H22N2O.C2H2O4
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1794760-28-3
PubChem ID 9817231
InChI Key FOQRKFCLRMMKAT-UHFFFAOYSA-N
Smiles O=C(O)C(O)=O.CCCN1CC(C2=CC(C3=CC=C(C)C=C3)=NO2)=CCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 18.62 50

Preparing Stock Solutions

The following data is based on the product molecular weight 372.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.37 mL 26.85 mL 53.7 mL
2.5 mM 1.07 mL 5.37 mL 10.74 mL
5 mM 0.54 mL 2.69 mL 5.37 mL
25 mM 0.11 mL 0.54 mL 1.07 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Akunne et al (1997) The pharmacology of the novel and selective sigma ligand, PD 144418. Neuropharmacology 36 51 PMID: 9144641

Lever et al (2014) Relationship between cerebral sigma-1 receptor occupancy and attenuation of cocaine's motor stimulatory effects in mice by PD144418. J.Pharmacol.Exp.Ther. 351 153 PMID: 25100754


If you know of a relevant reference for PD 144418 oxalate, please let us know.

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Keywords: PD 144418 oxalate, PD 144418 oxalate supplier, High, affinity, selective, σ1, sigma1, ligands, Receptors, PD144418, oxalate, Pfizer, Sigma1, 2606, Tocris Bioscience

2 Citations for PD 144418 oxalate

Citations are publications that use Tocris products. Selected citations for PD 144418 oxalate include:

Sánchez-Blázquez et al (2018) Sigma 1 Receptor Antagonists Inhibit Manic-Like Behaviors in Two Congenital Strains of Mice. Int J Neuropsychopharmacol 21 938 PMID: 29860313

Navarro et al (2015) Orexin-corticotropin-releasing factor receptor heteromers in the ventral tegmental area as targets for cocaine. Autophagy 35 6639 PMID: 25926444


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Literature in this Area

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