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PD 144418 oxalate
High affinity, selective σ1 ligand (Ki values are 0.08 and 1377 nM for σ1 and σ2 respectively). Displays no significant activity at a wide range of other receptors, ion channels and enzymes. Antagonizes mescaline-induced scratching in mice following i.p. administration. Also attenuates cocaine-induced hyperactivity in mice.
Sold for research purposes under agreement from Pfizer Inc.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 372.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||5.37 mL||26.85 mL||53.7 mL|
|2.5 mM||1.07 mL||5.37 mL||10.74 mL|
|5 mM||0.54 mL||2.69 mL||5.37 mL|
|25 mM||0.11 mL||0.54 mL||1.07 mL|
References are publications that support the biological activity of the product.
Akunne et al (1997) The pharmacology of the novel and selective sigma ligand, PD 144418. Neuropharmacology 36 51 PMID: 9144641
Lever et al (2014) Relationship between cerebral sigma-1 receptor occupancy and attenuation of cocaine's motor stimulatory effects in mice by PD144418. J.Pharmacol.Exp.Ther. 351 153 PMID: 25100754
If you know of a relevant reference for PD 144418 oxalate, please let us know.
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Keywords: PD 144418 oxalate, PD 144418 oxalate supplier, High, affinity, selective, σ1, sigma1, ligands, Receptors, PD144418, oxalate, Pfizer, Sigma1, 2606, Tocris Bioscience
2 Citations for PD 144418 oxalate
Citations are publications that use Tocris products. Selected citations for PD 144418 oxalate include:
Sánchez-Blázquez et al (2018) Sigma 1 Receptor Antagonists Inhibit Manic-Like Behaviors in Two Congenital Strains of Mice. Int J Neuropsychopharmacol 21 938 PMID: 29860313
Navarro et al (2015) Orexin-corticotropin-releasing factor receptor heteromers in the ventral tegmental area as targets for cocaine. Autophagy 35 6639 PMID: 25926444
Do you know of a great paper that uses PD 144418 oxalate from Tocris? Please let us know.
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