Parthenolide

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Cat.No. 0610 - Parthenolide | C15H20O3 | CAS No. 20554-84-1
Description: 5-HT release inhibitor
Chemical Name: [1aR-(1aR*,4E,7aS*,10aS*,-10bR*)]-2,3-6,7,7a,8,10a,10b-Octahydro-1a,5-dimethyl-8-methyleneoxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

The active principle of feverfew (Chrysanthemum parthenium), widely used as a herbal remedy for arthritis and migraine and as a febrifuge. Antisecretory, anti-inflammatory and spasmolytic; inhibits the release of 5-HT from blood platelets. Also inhibits generation of leukotriene B4 and thromboxane B2.

Compound Libraries

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Technical Data

M. Wt 248.32
Formula C15H20O3
Storage Desiccate at +4°C
Purity ≥98% (HPLC)
CAS Number 20554-84-1
PubChem ID 6473881
InChI Key KTEXNACQROZXEV-SLXBATTESA-N
Smiles C/C1=C\CC[C@]2(C)[C@@H](O2)[C@@H](OC([C@]3=C)=O)[C@H]3CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 12.42 100
ethanol 24.83 100

Preparing Stock Solutions

The following data is based on the product molecular weight 248.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.03 mL 20.14 mL 40.27 mL
5 mM 0.81 mL 4.03 mL 8.05 mL
10 mM 0.4 mL 2.01 mL 4.03 mL
50 mM 0.08 mL 0.4 mL 0.81 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Groenewegen and Heptinstall (1990) A comparison of the effects of an extract of feverfew and parthenolide, a component of feverfew, on human platelet activity in vitro. J.Pharm.Pharmacol. 42 553 PMID: 1981582

Heptinstall et al (1986) Compounds extracted from feverfew that have anti-secretory activity contain an α-methylene butyrolactone unit. J.Pharm.Pharmacol. 38 709 PMID: 2877077

Murphy et al (1988) Randomized double-blind placebo controlled trial of feverfew in migraine prevention. Lancet 2 189 PMID: 2899663

Sumner et al (1992) Inhibition of 5-lipoxygenase and cyclo-oxygenase in leukocytes by feverfew. Involvement of sesquiterpene lactones and other components. Biochem.Pharmacol. 43 2313 PMID: 1319159


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View Related Products by Target

Keywords: 5-HT release inhibitors inhibits Serotonin 5-Hydroxytryptamine Receptors 5-HT3 feverfew 5-HT-Related

1 Citation for Parthenolide

Citations are publications that use Tocris products. Selected citations for Parthenolide include:

Lee et al (2016) Mincle-mediated translational regulation is required for strong nitric oxide production and inflammation resolution. Anesth Analg 7 11322 PMID: 27089465


Do you know of a great paper that uses Parthenolide from Tocris? If so please let us know.

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Literature in this Area

5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Depression

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

Pathways for Parthenolide

Protocols

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