Parthenolide

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Cat.No. 0610 - Parthenolide | C15H20O3 | CAS No. 20554-84-1
Description: 5-HT release inhibitor
Chemical Name: [1aR-(1aR*,4E,7aS*,10aS*,-10bR*)]-2,3-6,7,7a,8,10a,10b-Octahydro-1a,5-dimethyl-8-methyleneoxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews (1)
Literature

Biological Activity

The active principle of feverfew (Chrysanthemum parthenium). Antisecretory, anti-inflammatory and spasmolytic; inhibits the release of 5-HT from blood platelets. Also inhibits activation of NF-κB, and generation of leukotriene B4 and thromboxane B2.

Compound Libraries

Parthenolide is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 248.32
Formula C15H20O3
Storage Desiccate at +4°C
Purity ≥98% (HPLC)
CAS Number 20554-84-1
PubChem ID 6473881
InChI Key KTEXNACQROZXEV-SLXBATTESA-N
Smiles C/C1=C\CC[C@]2(C)[C@@H](O2)[C@@H](OC([C@]3=C)=O)[C@H]3CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 12.42 100

Preparing Stock Solutions

The following data is based on the product molecular weight 248.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.03 mL 20.14 mL 40.27 mL
5 mM 0.81 mL 4.03 mL 8.05 mL
10 mM 0.4 mL 2.01 mL 4.03 mL
50 mM 0.08 mL 0.4 mL 0.81 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Groenewegen and Heptinstall (1990) A comparison of the effects of an extract of feverfew and parthenolide, a component of feverfew, on human platelet activity in vitro. J.Pharm.Pharmacol. 42 553 PMID: 1981582

Heptinstall et al (1986) Compounds extracted from feverfew that have anti-secretory activity contain an α-methylene butyrolactone unit. J.Pharm.Pharmacol. 38 709 PMID: 2877077

Sumner et al (1992) Inhibition of 5-lipoxygenase and cyclo-oxygenase in leukocytes by feverfew. Involvement of sesquiterpene lactones and other components. Biochem.Pharmacol. 43 2313 PMID: 1319159

Hehner et al (1998) Sesquiterpene lactones specifically inhibit activation of NF-κB by preventing the degradation of IκB-α and IκB-β. J.Biol.Chem. 273 1288 PMID: 9430659


If you know of a relevant reference for Parthenolide, please let us know.

Keywords: Parthenolide, Parthenolide supplier, 5-HT, release, inhibitors, inhibits, Serotonin, 5-Hydroxytryptamine, Receptors, 5-HT3, feverfew, 5-HT-Related, NF-kB/IkB, 0610, Tocris Bioscience

2 Citations for Parthenolide

Citations are publications that use Tocris products. Selected citations for Parthenolide include:

Lee et al (2016) Mincle-mediated translational regulation is required for strong nitric oxide production and inflammation resolution. Anesth Analg 7 11322 PMID: 27089465

Schwarz et al (2011) Parthenolide Blocks Cocaine's Effect on Spontaneous Firing Activity of DArgic Neurons in the Ventral Tegmental Area. Curr Neuropharmacol 9 17 PMID: 21886554


Do you know of a great paper that uses Parthenolide from Tocris? Please let us know.

Reviews for Parthenolide

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Parthenolide as a behavioral cocaine antagonist.
By One Pagan on 01/10/2018
Assay Type: In Vivo
Species: Other

Behavioral evaluation of antagonistic effects of parthenolide on cocaine effects in planarians

I have used Tocris’ Parthenolide (Cat. No. 0610) for a few years in my research program searching for behavioral antagonists of cocaine. This research has resulted in 5 peer-reviewed papers and the discovery story is included in a chapter of my book The First Brain: The Neuroscience of Planarians and in a review paper (shown in the figure). There are at least 4 more papers in preparation and the project is still going strong. In the initial phases of my project, I evaluated several suppliers of parthenolide and Tocris’ offering consistently came ahead in terms of customer service and compound purity, and I do not intend to change suppliers. I recommend this product and the company without reservation.

Reference
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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Depression

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.