PAOPA

Pricing Availability Delivery Time Qty
Cat.No. 5041 - PAOPA | C11H18N4O3 | CAS No. 114200-31-6
Description: Dopamine D2 receptor allosteric modulator
Chemical Name: (3R)-2-Oxo-3-[[(2S)-2-Pyrrolidinylcarbonyl]amino]-1-pyrrolidineacetamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Allosteric modulator of dopamine D2 receptors. Prevents and reverses behavioral and biochemical abnormalities in an amphetamine-sensitized animal model of schizophrenia.

Compound Libraries

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Technical Data

M. Wt 254.29
Formula C11H18N4O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 114200-31-6
PubChem ID 44281634
InChI Key QXHVGEXNEZRSGG-JGVFFNPUSA-N
Smiles O=C1[C@H](N[C@]([C@H]2NCCC2)=O)CCN1CC(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.43 100
water 25.43 100

Preparing Stock Solutions

The following data is based on the product molecular weight 254.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.93 mL 19.66 mL 39.33 mL
5 mM 0.79 mL 3.93 mL 7.87 mL
10 mM 0.39 mL 1.97 mL 3.93 mL
50 mM 0.08 mL 0.39 mL 0.79 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Beyaert et al (2013) PAOPA, a potent dopamine D2 receptor allosteric modulator, prevents and reverses behavioral and biochemical abnormalities in an amphetamine-sensitized preclinical animal model of schizophrenia. Eur.Neuropsychopharmacol. 23 253 PMID: 22658400

Tan et al (2011) Preclinical pharmacokinetic and toxicological evaluation of MIF-1 peptidomimetic, PAOPA: examining the pharmacology of a selective dopamine D2 receptor allosteric modulator for the treatment of schizophrenia. Peptides 42 89 PMID: 23416534

Dyck et al (2011) PAOPA, a potent analogue of Pro-Leu-glycinamide and allosteric modulator of the dopamine D2 receptor, prevents NMDA receptor antagonist (MK-801)-induced deficits in social interaction in the rat: implications for the treatment of negative symptoms in schi Schizophr.Res. 125 89 PMID: 21036015


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Keywords: Dopamine D2 receptor allosteric modulators dopaminergic schizophrenia D2 Receptors

Citations for PAOPA

Citations are publications that use Tocris products.

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Literature in this Area

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Pathways for PAOPA

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