P21d hydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 6073 - P21d hydrochloride | C23H22FN7O2.HCl
Description: Potent and selective Brk inhibitor
Chemical Name: [4-[[6-Cyclopropyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]-3-fluorophenyl]-4-morpholinylmethanone hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent and selective breast tumor kinase (Brk) inhibitor (IC50 = 30 nM). Exhibits >650-fold selectively for Brk over Aurora B kinase and Lck. Downregulates SNAIL protein, restores E-cadherin expression and suppresses migration in breast cancer cells. Also active in vivo and orally bioavailable.

Technical Data

M. Wt 483.93
Formula C23H22FN7O2.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
InChI Key GWHGHKMCIUENCZ-UHFFFAOYSA-N
Smiles Cl.FC1=C(NC2=NC(=CN3C(=CN=C23)C2=CNN=C2)C2CC2)C=CC(=C1)C(=O)N1CCOCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 48.39 100

Preparing Stock Solutions

The following data is based on the product molecular weight 483.93. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.07 mL 10.33 mL 20.66 mL
5 mM 0.41 mL 2.07 mL 4.13 mL
10 mM 0.21 mL 1.03 mL 2.07 mL
50 mM 0.04 mL 0.21 mL 0.41 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Zeng et al (2011) Discovery of novel imidazo[1,2-a]pyrazin-8-amines as Brk/PTK6 inhibitors. Bioorg.Med.Chem.Lett 21 5870 PMID: 21855335

Ito et al (2016) PTK6 inhibition suppresses metastases of triple-negative breast cancer via SNAIL-dependent E-cadherin regulation. Cancer Res. 76 4406 PMID: 27302163


If you know of a relevant reference for P21d hydrochloride, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Src Kinase Inhibitors

Keywords: P21d hydrochloride, supplier, Potent, selective, breast, tumor, kinase, Brk, PTK6, inhibitors, inhibits, orally, bioavailable, Src, Kinases, Tocris Bioscience

Citations for P21d hydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for P21d hydrochloride. Do you know of a great paper that uses P21d hydrochloride from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Immunology

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases

Pathways for P21d hydrochloride

Protocols

TODO: Add Protocols