Discontinued Product

OXSI 2 (Cat. No. 6012) has been withdrawn from sale for commercial reasons.
Description: Potent Syk kinase inhibitor; also inhibits assembly of NLRP3 inflammasomes
Chemical Name: 2,3-Dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2-oxo-1H-indole-5-sulfonamide
Purity: ≥98% (HPLC)
Literature (3)

Biological Activity for OXSI 2

OXSI 2 is a potent Syk kinase inhibitor (IC50 = 14 nM). Inhibits assembly of NLRP3 inflammasomes induced by Nigericin (Cat.No. 4312). Also inhibits the activation of caspase-1, IL-1β processing and release, mitochondrial ROS generation and pyroptic cell death in mouse macrophage cells.

Technical Data for OXSI 2

M. Wt 353.39
Formula C18H15N3O3S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 622387-85-3
PubChem ID 24906266
Smiles CN1C=C(/C=C2C(NC3=CC=C(C=C\23)S(N)(=O)=O)=O)C4=CC=CC=C14

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for OXSI 2

References are publications that support the biological activity of the product.

Lai et al (2003) Potent small molecule inhibitors of spleen tyrosine kinase (Syk). Bioorg.Med.Chem.Lett. 13 3111 PMID: 12941345

Yaron et al (2016) The oxindole Syk inhibitor OXSI-2 blocks nigericin-induced inflammasome signaling and pyroptosis independent of potassium efflux. Biochem.Biophys.Res.Commun. 472 545 PMID: 26970308

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Keywords: OXSI 2, OXSI 2 supplier, OXSI2, Inhibitors, inhibits, Syk, kinase, NLRPL3, inflammasome, caspase-1, IL-1beta, IL-1b, IL-1β, mitochondria, ROS, pyroptosis, inflammation, Kinase, Inflammasomes, 6012, Tocris Bioscience

Citations for OXSI 2

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