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Cat.No. 6012 - OXSI 2 | C18H15N3O3S | CAS No. 622387-85-3
Description: Potent Syk kinase inhibitor; also inhibits assembly of NLRP3 inflammasomes
Chemical Name: 2,3-Dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2-oxo-1H-indole-5-sulfonamide
Purity: ≥98% (HPLC)
Literature (3)

Biological Activity for OXSI 2

OXSI 2 is a potent Syk kinase inhibitor (IC50 = 14 nM). Inhibits assembly of NLRP3 inflammasomes induced by Nigericin (Cat.No. 4312). Also inhibits the activation of caspase-1, IL-1β processing and release, mitochondrial ROS generation and pyroptic cell death in mouse macrophage cells.

Technical Data for OXSI 2

M. Wt 353.39
Formula C18H15N3O3S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 622387-85-3
PubChem ID 24906266
Smiles CN1C=C(/C=C2C(NC3=CC=C(C=C\23)S(N)(=O)=O)=O)C4=CC=CC=C14

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for OXSI 2

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 35.34 100

Preparing Stock Solutions for OXSI 2

The following data is based on the product molecular weight 353.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.83 mL 14.15 mL 28.3 mL
5 mM 0.57 mL 2.83 mL 5.66 mL
10 mM 0.28 mL 1.41 mL 2.83 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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References for OXSI 2

References are publications that support the biological activity of the product.

Lai et al (2003) Potent small molecule inhibitors of spleen tyrosine kinase (Syk). Bioorg.Med.Chem.Lett. 13 3111 PMID: 12941345

Yaron et al (2016) The oxindole Syk inhibitor OXSI-2 blocks nigericin-induced inflammasome signaling and pyroptosis independent of potassium efflux. Biochem.Biophys.Res.Commun. 472 545 PMID: 26970308

If you know of a relevant reference for OXSI 2, please let us know.

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Keywords: OXSI 2, OXSI 2 supplier, OXSI2, Inhibitors, inhibits, Syk, kinase, NLRPL3, inflammasome, caspase-1, IL-1beta, IL-1b, IL-1β, mitochondria, ROS, pyroptosis, inflammation, Kinase, Inflammasomes, 6012, Tocris Bioscience

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