Potent Syk kinase inhibitor (IC50 = 14 nM). Inhibits assembly of NLRP3 inflammasomes induced by Nigericin (Cat.No. 4312). Also inhibits the activation of caspase-1, IL-1β processing and release, mitochondrial ROS generation and pyroptic cell death in mouse macrophage cells.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 353.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.83 mL||14.15 mL||28.3 mL|
|5 mM||0.57 mL||2.83 mL||5.66 mL|
|10 mM||0.28 mL||1.41 mL||2.83 mL|
|50 mM||0.06 mL||0.28 mL||0.57 mL|
References are publications that support the biological activity of the product.
Lai et al (2003) Potent small molecule inhibitors of spleen tyrosine kinase (Syk). Bioorg.Med.Chem.Lett. 13 3111 PMID: 12941345
Yaron et al (2016) The oxindole Syk inhibitor OXSI-2 blocks nigericin-induced inflammasome signaling and pyroptosis independent of potassium efflux. Biochem.Biophys.Res.Commun. 472 545 PMID: 26970308
If you know of a relevant reference for OXSI 2, please let us know.
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Keywords: OXSI 2, OXSI 2 supplier, OXSI2, Inhibitors, inhibits, Syk, kinase, NLRPL3, inflammasome, caspase-1, IL-1beta, IL-1b, IL-1β, mitochondria, ROS, pyroptosis, inflammation, Kinase, Inflammasomes, 6012, Tocris Bioscience
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