OXF BD 02

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Cat.No. 4928 - OXF BD 02 | C18H17NO3 | CAS No. 1429129-68-9
Description: Selective BRD4(1) inhibitor
Chemical Name: 3-(3,5-Dimethyl-4-isoxazolyl)-5-hydroxy-α-phenylbenzenemethanol
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (6)

Biological Activity for OXF BD 02

OXF BD 02 is a selective inhibitor of the first bromodomain of BRD4 (BRD4(1)) (IC50 = 382 nM). Exhibits 2-3-fold selectivity for BRD4(1) over the CBP bromodomain and has little affinity for a range of other bromodomains. Reduces viability of lung adenocarcinoma cell lines and attenuates proliferation of MV-4-11 leukemia cells. Cell permeable.

Licensing Information

Sold with the agreement of the University of Oxford

Technical Data for OXF BD 02

M. Wt 295.33
Formula C18H17NO3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1429129-68-9
PubChem ID 56929801
InChI Key FEQUIPXIENTMJN-UHFFFAOYSA-N
Smiles OC1=CC(C2=C(C)ON=C2C)=CC(C(O)C3=CC=CC=C3)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for OXF BD 02

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.53 100
ethanol 2.95 10 with gentle warming

Preparing Stock Solutions for OXF BD 02

The following data is based on the product molecular weight 295.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.39 mL 16.93 mL 33.86 mL
5 mM 0.68 mL 3.39 mL 6.77 mL
10 mM 0.34 mL 1.69 mL 3.39 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

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References for OXF BD 02

References are publications that support the biological activity of the product.

Hewings et al (2011) 3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands. J.Med.Chem. 54 6761 PMID: 21851057

Hewings et al (2013) Optimization of 3,5-dimethylisoxazole derivatives as potent bromodomain ligands. J.Med.Chem. 56 3217 PMID: 23517011


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Keywords: OXF BD 02, OXF BD 02 supplier, OXFBD02, selective, bromodomains, BRD, BRD4(1), inhibitors, cell, permeable, antiproliferative, inhibits, Bromodomains, 4928, Tocris Bioscience

Citations for OXF BD 02

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Literature in this Area

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