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Submit ReviewOrphanin FQ (1-11)
Description: Potent NOP agonist; displays analgesic properties
Alternative Names: Nociceptin (1-11)
Biological Activity for Orphanin FQ (1-11)
Orphanin FQ (1-11) is a peptide fragment containing amino acids 1-11 of Nociceptin (Cat. No. 0910). Potent agonist of the ORL1/KOR-3 receptor (Ki = 55 nM); displays no affinity for opioid receptors, including μ, δ, κ1 and κ3 receptors (Ki >1000 nM). Displays analgesic properties in CD-1 mice.
Technical Data for Orphanin FQ (1-11)
| M. Wt | 1098.2 |
| Formula | C49H75N15O14 |
| Sequence | FGGFTGARKSA |
| Storage | Store at -20°C |
| CAS Number | 178249-41-7 |
| PubChem ID | 10653748 |
| InChI Key | BBTOUBACUUPBRQ-KCKZSKPYSA-N |
| Smiles | [H]N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Orphanin FQ (1-11)
References for Orphanin FQ (1-11)
References are publications that support the biological activity of the product.
Rossi et al (1997) Pharmacological characterization of orphanin FQ/nociceptin and its fragments. J.Pharmacol.Exp.Ther. 282 858 PMID: 9262352
Rossi et al (1998) Orphanin FQ/nociceptin analgesia in the rat. Brain Res. 792 327 PMID: 9593974
Reinscheid et al (1996) Structure-activity relationship studies on the novel neuropeptide orphanin FQ. J.Biol.Chem. 271 14163 PMID: 8662940
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Keywords: Orphanin FQ (1-11), Orphanin FQ (1-11) supplier, Nociceptin, Receptors, agonists, NOP, ORL1, KOR-3, analgesic, opioid, (1-11), 3932, Tocris Bioscience
Citations for Orphanin FQ (1-11)
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Currently there are no citations for Orphanin FQ (1-11).
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.