Orphanin FQ (1-11)

Pricing Availability   Qty
Cat.No. 3932 - Orphanin FQ (1-11) | Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala | CAS No. 178249-41-7
Description: Potent NOP agonist; displays analgesic properties
Alternative Names: Nociceptin (1-11)
Literature (5)

Biological Activity

Peptide fragment containing amino acids 1-11 of Nociceptin (Cat. No. 0910). Potent agonist of the ORL1/KOR-3 receptor (Ki = 55 nM); displays no affinity for opioid receptors, including μ, δ, κ1 and κ3 receptors (Ki >1000 nM). Displays analgesic properties in CD-1 mice.

Technical Data

M. Wt 1098.2
Formula C49H75N15O14
Storage Store at -20°C
CAS Number 178249-41-7
PubChem ID 10653748
Smiles [H]N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 2 mg/ml in 20% acetonitrile / water


References are publications that support the biological activity of the product.

Rossi et al (1997) Pharmacological characterization of orphanin FQ/nociceptin and its fragments. J.Pharmacol.Exp.Ther. 282 858 PMID: 9262352

Rossi et al (1998) Orphanin FQ/nociceptin analgesia in the rat. Brain Res. 792 327 PMID: 9593974

Reinscheid et al (1996) Structure-activity relationship studies on the novel neuropeptide orphanin FQ. J.Biol.Chem. 271 14163 PMID: 8662940

If you know of a relevant reference for Orphanin FQ (1-11), please let us know.

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Keywords: Orphanin FQ (1-11), Orphanin FQ (1-11) supplier, Nociceptin, Receptors, agonists, NOP, ORL1, KOR-3, analgesic, opioid, (1-11), 3932, Tocris Bioscience

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