Orphanin FQ (1-11)
Peptide fragment containing amino acids 1-11 of Nociceptin (Cat. No. 0910). Potent agonist of the ORL1/KOR-3 receptor (Ki = 55 nM); displays no affinity for opioid receptors, including μ, δ, κ1 and κ3 receptors (Ki >1000 nM). Displays analgesic properties in CD-1 mice.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 2 mg/ml in 20% acetonitrile / water|
Preparing Stock Solutions
The following data is based on the product molecular weight 1098.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.91 mL||4.55 mL||9.11 mL|
|5 mM||0.18 mL||0.91 mL||1.82 mL|
|10 mM||0.09 mL||0.46 mL||0.91 mL|
|50 mM||0.02 mL||0.09 mL||0.18 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Rossi et al (1997) Pharmacological characterization of orphanin FQ/nociceptin and its fragments. J.Pharmacol.Exp.Ther. 282 858 PMID: 9262352
Rossi et al (1998) Orphanin FQ/nociceptin analgesia in the rat. Brain Res. 792 327 PMID: 9593974
Reinscheid et al (1996) Structure-activity relationship studies on the novel neuropeptide orphanin FQ. J.Biol.Chem. 271 14163 PMID: 8662940
If you know of a relevant reference for Orphanin FQ (1-11), please let us know.
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Keywords: Nociceptin Receptors agonists NOP ORL1 KOR-3 analgesic opioid Nociceptin (1-11) NOP Receptors
Citations for Orphanin FQ (1-11)
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