Orphanin FQ (1-11)

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Cat.No. 3932 - Orphanin FQ (1-11) | Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala | CAS No. 178249-41-7
Description: Potent NOP agonist; displays analgesic properties
Alternative Names: Nociceptin (1-11)
Datasheet
Citations
Literature

Biological Activity

Peptide fragment containing amino acids 1-11 of Nociceptin (Cat. No. 0910). Potent agonist of the ORL1/KOR-3 receptor (Ki = 55 nM); displays no affinity for opioid receptors, including μ, δ, κ1 and κ3 receptors (Ki >1000 nM). Displays analgesic properties in CD-1 mice.

Technical Data

M. Wt 1098.2
Formula C49H75N15O14
Sequence FGGFTGARKSA
Storage Store at -20°C
CAS Number 178249-41-7
PubChem ID 10653748
InChI Key BBTOUBACUUPBRQ-KCKZSKPYSA-N
Smiles [H]N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 2 mg/ml in 20% acetonitrile / water

Preparing Stock Solutions

The following data is based on the product molecular weight 1098.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.91 mL 4.55 mL 9.11 mL
5 mM 0.18 mL 0.91 mL 1.82 mL
10 mM 0.09 mL 0.46 mL 0.91 mL
50 mM 0.02 mL 0.09 mL 0.18 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Rossi et al (1997) Pharmacological characterization of orphanin FQ/nociceptin and its fragments. J.Pharmacol.Exp.Ther. 282 858 PMID: 9262352

Rossi et al (1998) Orphanin FQ/nociceptin analgesia in the rat. Brain Res. 792 327 PMID: 9593974

Reinscheid et al (1996) Structure-activity relationship studies on the novel neuropeptide orphanin FQ. J.Biol.Chem. 271 14163 PMID: 8662940


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Keywords: Nociceptin Receptors agonists NOP ORL1 KOR-3 analgesic opioid Nociceptin (1-11) NOP Receptors

Citations for Orphanin FQ (1-11)

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