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Discontinued ProductOrg 48762-0 (Cat. No. 6014) has been withdrawn from sale for commercial reasons.
Biological Activity for Org 48762-0
Org 48762-0 is a selective p38α and β kinase inhibitor (EC50 = 0.1 μM for p38α). Selective for p38α/β over a panel of 48 other human kinases. Inhibits LPS-induced TNFα release from PBMCs. Also inhibits cytokine release in an LPS-induced endotoxemia model in mice. Orally bioavailable.
Technical Data for Org 48762-0
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References for Org 48762-0
References are publications that support the biological activity of the product.
Mihara et al (2008) A potent and selective p38 inhibitor protects against bone damage in murine collagen-induced arthritis: a comparison with neutralization of mouse TNFalpha. Br.J.Pharmacol. 154 153 PMID: 18297096
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Keywords: Org 48762-0, Org 48762-0 supplier, Org48762-0, MAPK, mitogen-activated, protein, kinases, inhibitors, inhibits, p38, α, β, alpha, beta, selective, orally, bioavailable, 6014, Tocris Bioscience
Citations for Org 48762-0
Citations are publications that use Tocris products.
Currently there are no citations for Org 48762-0.
Reviews for Org 48762-0
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
MAPK Signaling Scientific Review
MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.