You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for Oncrasin 1
Oncrasin 1 is a proapoptotic agent that induces abnormal nuclear aggregation of PKCι and suppresses RNA transcription. Exhibits antiproliferative effects against various human tumor cell lines with K-Ras mutations (IC50 ≤ 3 μM) with minimal effects on normal epithelial cells and inhibits human xenograft growth by 75% in vivo.
Technical Data for Oncrasin 1
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Oncrasin 1
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Oncrasin 1
The following data is based on the product molecular weight 269.73. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.71 mL||18.54 mL||37.07 mL|
|5 mM||0.74 mL||3.71 mL||7.41 mL|
|10 mM||0.37 mL||1.85 mL||3.71 mL|
|50 mM||0.07 mL||0.37 mL||0.74 mL|
References for Oncrasin 1
References are publications that support the biological activity of the product.
Guo et al (2009) Interruption of RNA processing machinery by a small compound, 1-[(4-chlorophenyl)methyl]-1H-indole-3-carboxaldehyde (oncrasin-1). Mol.Cancer Ther. 8 441 PMID: 19208825
Guo et al (2007) Identification of a small molecule with synthetic lethality for k-Ras and protein kinase C iota. Cancer Res. 68 7403
If you know of a relevant reference for Oncrasin 1, please let us know.
Keywords: Oncrasin 1, Oncrasin 1 supplier, Induces, abnormal, nuclear, aggregation, PKCiota, proapoptotic, Protein, Kinases, C, Apoptosis, Inducers, Oncrasin1, Kinase, 3427, Tocris Bioscience
Citations for Oncrasin 1
Citations are publications that use Tocris products.
Currently there are no citations for Oncrasin 1. Do you know of a great paper that uses Oncrasin 1 from Tocris? Please let us know.
Reviews for Oncrasin 1
There are currently no reviews for this product. Be the first to review Oncrasin 1 and earn rewards!
Have you used Oncrasin 1?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.