Oncrasin 1

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Cat.No. 3427 - Oncrasin 1 | C16H12ClNO | CAS No. 75629-57-1
Description: Induces abnormal nuclear aggregation of PKCι; proapoptotic
Chemical Name: 1-[(4-Chlorophenyl)methyl]-1H-indole-3-carboxaldehyde
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (3)

Biological Activity

Proapoptotic agent that induces abnormal nuclear aggregation of PKCι and suppresses RNA transcription. Exhibits antiproliferative effects against various human tumor cell lines with K-Ras mutations (IC50 ≤ 3 μM) with minimal effects on normal epithelial cells and inhibits human xenograft growth by 75% in vivo.

Technical Data

M. Wt 269.73
Formula C16H12ClNO
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 75629-57-1
PubChem ID 872445
InChI Key ZDRQMXCSSAPUMM-UHFFFAOYSA-N
Smiles O=CC2=CN(CC3=CC=C(Cl)C=C3)C1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 26.97 100
ethanol 6.74 25

Preparing Stock Solutions

The following data is based on the product molecular weight 269.73. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.71 mL 18.54 mL 37.07 mL
5 mM 0.74 mL 3.71 mL 7.41 mL
10 mM 0.37 mL 1.85 mL 3.71 mL
50 mM 0.07 mL 0.37 mL 0.74 mL

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References

References are publications that support the biological activity of the product.

Guo et al (2009) Interruption of RNA processing machinery by a small compound, 1-[(4-chlorophenyl)methyl]-1H-indole-3-carboxaldehyde (oncrasin-1). Mol.Cancer Ther. 8 441 PMID: 19208825

Guo et al (2007) Identification of a small molecule with synthetic lethality for k-Ras and protein kinase C iota. Cancer Res. 68 7403


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