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Biological Activity for Olmesartan
Olmesartan is a potent angiotensin II type I (AT1) receptor antagonist (IC50 = 6.7 nM at hAT1 receptors). Improves cognitive function in a mouse model of hypertension- and hyperlipidemia-associated cognitive decline; ameliorates arterial stiffness in a rat model of chronic renal failure.
Compound Libraries for Olmesartan
Technical Data for Olmesartan
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Olmesartan
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Olmesartan
The following data is based on the product molecular weight 446.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||11.2 mL||55.99 mL||111.98 mL|
|1 mM||2.24 mL||11.2 mL||22.4 mL|
|2 mM||1.12 mL||5.6 mL||11.2 mL|
|10 mM||0.22 mL||1.12 mL||2.24 mL|
References for Olmesartan
References are publications that support the biological activity of the product.
Mogi et al (2007) Inhibition of cognitive decline in mice fed a high-salt and cholesterol diet by the angiotensin receptor blocker, olmes. Neuropharmacology 53 899 PMID: 18028965
Chuang et al (2012) Effects of olmes. on arterial stiffness in rats with chronic renal failure. Cardiovasc.Diabetol. 11 66 PMID: 22694778
Ojima et al (2011) In vitro antagonistic properties of a new angiotensin type 1 receptor blocker, azilsartan, in receptor binding and function studies. J.Pharmacol.Exp.Ther. 336 801 PMID: 21123673
If you know of a relevant reference for Olmesartan, please let us know.
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1 Citation for Olmesartan
Citations are publications that use Tocris products. Selected citations for Olmesartan include:
Pedersen (2021) A novel luminescence-based-β-arrestin recruitment assay for unmodified receptors. J Biol. Chem. 296 100503 PMID: 33684444
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Literature in this Area
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