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Description: Potent AT1 antagonist
Chemical Name: 4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid
Purity: ≥99% (HPLC)
Citations (2)

Biological Activity for Olmesartan

Olmesartan is a potent angiotensin II type I (AT1) receptor antagonist (IC50 = 6.7 nM at hAT1 receptors). Improves cognitive function in a mouse model of hypertension- and hyperlipidemia-associated cognitive decline; ameliorates arterial stiffness in a rat model of chronic renal failure.

Compound Libraries for Olmesartan

Olmesartan is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Olmesartan

M. Wt 446.5
Formula C24H26N6O3
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 144689-24-7
PubChem ID 158781
Smiles CCCC1=NC(C(C)(C)O)=C(C(O)=O)N1CC2=CC=C(C3=CC=CC=C3C4=NN=NN4)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Olmesartan

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 8.93 20

Preparing Stock Solutions for Olmesartan

The following data is based on the product molecular weight 446.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 11.2 mL 55.99 mL 111.98 mL
1 mM 2.24 mL 11.2 mL 22.4 mL
2 mM 1.12 mL 5.6 mL 11.2 mL
10 mM 0.22 mL 1.12 mL 2.24 mL

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Product Datasheets for Olmesartan

Certificate of Analysis / Product Datasheet
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References for Olmesartan

References are publications that support the biological activity of the product.

Mogi et al (2007) Inhibition of cognitive decline in mice fed a high-salt and cholesterol diet by the angiotensin receptor blocker, olmes. Neuropharmacology 53 899 PMID: 18028965

Chuang et al (2012) Effects of olmes. on arterial stiffness in rats with chronic renal failure. Cardiovasc.Diabetol. 11 66 PMID: 22694778

Ojima et al (2011) In vitro antagonistic properties of a new angiotensin type 1 receptor blocker, azilsartan, in receptor binding and function studies. J.Pharmacol.Exp.Ther. 336 801 PMID: 21123673

If you know of a relevant reference for Olmesartan, please let us know.

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Keywords: Olmesartan, Olmesartan supplier, rnh, 6270, rnh6270, olmetec, benicar, potent, antagonists, angiotensin, II, receptors, blockers, ARBs, AT1, antihypertensive, Angiotensin, Receptors, 4616, Tocris Bioscience

2 Citations for Olmesartan

Citations are publications that use Tocris products. Selected citations for Olmesartan include:

Pedersen (2021) A novel luminescence-based-β-arrestin recruitment assay for unmodified receptors. J Biol. Chem. 296 100503 PMID: 33684444

Robert J et al (2019) Distinctive Activation Mechanism for Angiotensin Receptor Revealed by a Synthetic Nanobody. Cell 176 479-490.e12 PMID: 30639100

Do you know of a great paper that uses Olmesartan from Tocris? Please let us know.

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