Olmesartan

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Cat.No. 4616 - Olmesartan | C24H26N6O3 | CAS No. 144689-24-7
Description: Potent AT1 antagonist; metabolite of Olmesartan medoxomil (Cat. No. 4620)
Chemical Name: 4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid
Purity: ≥99% (HPLC)
Datasheet
Citations
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Literature

Biological Activity

Potent angiotensin II type I (AT1) receptor antagonist (IC50 = 6.7 nM at hAT1 receptors). Improves cognitive function in a mouse model of hypertension- and hyperlipidemia-associated cognitive decline; ameliorates arterial stiffness in a rat model of chronic renal failure. Metabolite of Olmesartan medoxomil (Cat. No. 4620).

Compound Libraries

Olmesartan is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 446.5
Formula C24H26N6O3
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 144689-24-7
PubChem ID 158781
InChI Key VTRAEEWXHOVJFV-UHFFFAOYSA-N
Smiles CCCC1=NC(C(C)(C)O)=C(C(O)=O)N1CC2=CC=C(C3=CC=CC=C3C4=NN=NN4)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 8.93 20

Preparing Stock Solutions

The following data is based on the product molecular weight 446.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 11.2 mL 55.99 mL 111.98 mL
1 mM 2.24 mL 11.2 mL 22.4 mL
2 mM 1.12 mL 5.6 mL 11.2 mL
10 mM 0.22 mL 1.12 mL 2.24 mL

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References

References are publications that support the biological activity of the product.

Mogi et al (2007) Inhibition of cognitive decline in mice fed a high-salt and cholesterol diet by the angiotensin receptor blocker, olmesartan. Neuropharmacology 53 899 PMID: 18028965

Chuang et al (2012) Effects of olmesartan on arterial stiffness in rats with chronic renal failure. Cardiovasc.Diabetol. 11 66 PMID: 22694778

Ojima et al (2011) In vitro antagonistic properties of a new angiotensin type 1 receptor blocker, azilsartan, in receptor binding and function studies. J.Pharmacol.Exp.Ther. 336 801 PMID: 21123673


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Citations for Olmesartan

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