Olmesartan medoxomil

Discontinued Product

Unfortunately Olmesartan medoxomil (Cat. No. 4620) has been withdrawn from sale for commercial reasons.
Cat.No. 4620 - Olmesartan medoxomil | C29H30N6O6 | CAS No. 144689-63-4
Description: Selective non-peptide AT1 antagonist; prodrug of Olmesartan
Chemical Name: 4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-Imidazole-5-carboxylic acid-(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Prodrug metabolised in vivo to Olmesartan (Cat. No. 4616), a selective non-peptide angiotensin II type I receptor (AT1) antagonist. Selectively inhibits angiotensin II binding to AT1 receptors in bovine adrenal cortical membranes (IC50 = 7.7 nM), with no effect on AT2 receptors.

Compound Libraries

Olmesartan medoxomil is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 558.59
Formula C29H30N6O6
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 144689-63-4
PubChem ID 130881
InChI Key UQGKUQLKSCSZGY-UHFFFAOYSA-N
Smiles CCCC1=NC(C(C)(C)O)=C(C(OCC(O5)=C(C)OC5=O)=O)N1CC2=CC=C(C3=CC=CC=C3C4=NN=NN4)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 558.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.79 mL 8.95 mL 17.9 mL
5 mM 0.36 mL 1.79 mL 3.58 mL
10 mM 0.18 mL 0.9 mL 1.79 mL
50 mM 0.04 mL 0.18 mL 0.36 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Kim et al (1997) Effects of angiotensin AT1 receptor antagonist on volume overload-induced cardiac gene expression in rats. Hypertens.Res. 20 133 PMID: 9220278

Mizuno et al (1995) Pharmacology of CS-866, a novel nonpeptide angiotensin II receptor antagonist. Eur.J.Pharmacol. 285 181 PMID: 8566137

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Keywords: Olmesartan medoxomil, supplier, CS866, antagonists, RNH-6270, AT1, receptors, angiotensin, II, type, I, receptor, Angiotensin, AT1, Receptors, Tocris Bioscience

Citations for Olmesartan medoxomil

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Pathways for Olmesartan medoxomil

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