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Prodrug metabolised in vivo to Olmesartan (Cat. No. 4616), a selective non-peptide angiotensin II type I receptor (AT1) antagonist. Selectively inhibits angiotensin II binding to AT1 receptors in bovine adrenal cortical membranes (IC50 = 7.7 nM), with no effect on AT2 receptors.
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The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Kim et al (1997) Effects of angiotensin AT1 receptor antagonist on volume overload-induced cardiac gene expression in rats. Hypertens.Res. 20 133 PMID: 9220278
Mizuno et al (1995) Pharmacology of CS-866, a novel nonpeptide angiotensin II receptor antagonist. Eur.J.Pharmacol. 285 181 PMID: 8566137
Keywords: Olmesartan medoxomil, Olmesartan medoxomil supplier, CS866, antagonists, RNH-6270, AT1, receptors, angiotensin, II, type, I, receptor, Angiotensin, Receptors, 4620, Tocris Bioscience
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