Olmesartan medoxomil

Discontinued Product

Olmesartan medoxomil (Cat. No. 4620) has been withdrawn from sale for commercial reasons.
Description: Selective non-peptide AT1 antagonist; prodrug of Olmesartan
Chemical Name: 4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-Imidazole-5-carboxylic acid-(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester
Purity: ≥98% (HPLC)

Biological Activity for Olmesartan medoxomil

Prodrug metabolised in vivo to Olmesartan (Cat. No. 4616), a selective non-peptide angiotensin II type I receptor (AT1) antagonist. Selectively inhibits angiotensin II binding to AT1 receptors in bovine adrenal cortical membranes (IC50 = 7.7 nM), with no effect on AT2 receptors.

Compound Libraries for Olmesartan medoxomil

Olmesartan medoxomil is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Olmesartan medoxomil

M. Wt 558.59
Formula C29H30N6O6
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 144689-63-4
PubChem ID 130881
Smiles CCCC1=NC(C(C)(C)O)=C(C(OCC(O5)=C(C)OC5=O)=O)N1CC2=CC=C(C3=CC=CC=C3C4=NN=NN4)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Olmesartan medoxomil

References for Olmesartan medoxomil

References are publications that support the biological activity of the product.

Kim et al (1997) Effects of angiotensin AT1 receptor antagonist on volume overload-induced cardiac gene expression in rats. Hypertens.Res. 20 133 PMID: 9220278

Mizuno et al (1995) Pharmacology of CS-866, a novel nonpeptide angiotensin II receptor antagonist. Eur.J.Pharmacol. 285 181 PMID: 8566137

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Keywords: Olmesartan medoxomil, Olmesartan medoxomil supplier, CS866, antagonists, RNH-6270, AT1, receptors, angiotensin, II, type, I, receptor, Angiotensin, Receptors, 4620, Tocris Bioscience

Citations for Olmesartan medoxomil

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