OD 36 hydrochloride

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Cat.No. 6598 - OD 36 hydrochloride | C16H15ClN4O2.HCl | CAS No. 1638644-62-8
Description: Potent RIP2 kinase inhibitor
Chemical Name: 6-Chloro-10,11,14,17-tetrahydro-13H-1,16-etheno-4,8-metheno-1H-pyrazolo[3,4-g][1,14,4,6]dioxadiazacyclohexadecine hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity

Potent receptor-interacting protein kinase 2 (RIPK2) inhibitor (IC50 = 5.3 nM). Displays similar % inhibition against ALK-2 and SIK2 at 100 nM. Downregulates expression of a panel of RIPK2-dependent genes. Inhibits recruitment of inflammatory cells in a mouse MDP-induced peritonitis model.

Technical Data

M. Wt 367.23
Formula C16H15ClN4O2.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1638644-62-8
Smiles ClC1=CC(C2=C3N=C(NCCOCCO4)C=CN3N=C2)=CC4=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.72 100
ethanol 1.84 5

Preparing Stock Solutions

The following data is based on the product molecular weight 367.23. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.72 mL 13.62 mL 27.23 mL
5 mM 0.54 mL 2.72 mL 5.45 mL
10 mM 0.27 mL 1.36 mL 2.72 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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References

References are publications that support the biological activity of the product.

Tigno-Aranjuez et al (2014) In vivo inhibition of RIPK2 kinase alleviates inflammatory disease. J.Biol.Chem. 289 29651 PMID: 25213858

Sánchez-Duffhues et al (2019) Development of macrocycle kinase inhibitors for ALK2 using Fibrodysplasia ossificans progressiva-derived endothelial cells. JBMRPlus


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