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OD 36 hydrochloride is a potent receptor-interacting protein kinase 2 (RIPK2) inhibitor (IC50 = 5.3 nM). Displays similar % inhibition against ALK-2 and SIK2 at 100 nM. Downregulates expression of a panel of RIPK2-dependent genes. Inhibits recruitment of inflammatory cells in a mouse MDP-induced peritonitis model.
OD 36 hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 367.23. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.72 mL||13.62 mL||27.23 mL|
|5 mM||0.54 mL||2.72 mL||5.45 mL|
|10 mM||0.27 mL||1.36 mL||2.72 mL|
|50 mM||0.05 mL||0.27 mL||0.54 mL|
References are publications that support the biological activity of the product.
Tigno-Aranjuez et al (2014) In vivo inhibition of RIPK2 kinase alleviates inflammatory disease. J.Biol.Chem. 289 29651 PMID: 25213858
Sánchez-Duffhues et al (2019) Development of macrocycle kinase inhibitors for ALK2 using Fibrodysplasia ossificans progressiva-derived endothelial cells. JBMRPlus 3 e10230 PMID: 31768489
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Keywords: OD 36 hydrochloride, OD 36 hydrochloride supplier, OD36, hydrochloride, anti, inflammatory, RIPK2, RIP, kinase, inhibitors, inhibits, receptor-interacting, protein, 2, Kinases, 6598, Tocris Bioscience
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