OAC-1

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Cat.No. 4887 - OAC-1 | C14H11N3O | CAS No. 300586-90-7
Description: Oct4 activator; enhances iPSC reprogramming efficiency
Chemical Name: N-1H-Pyrrolo[2,3-c]pyridin-5-ylbenzamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Oct4 activator. Enhances and accelerates iPSC reprogramming in the presence of 4F (Oct4, Sox2, c-Myc and Klf4) by ~20-fold compared to 4F alone. Induces mRNA expression of Oct4, Sox2 and Nanog and also Tet1. Displays no effects on p53-p21 pathway or Wnt-β-catenin signaling.

Compound Libraries

OAC-1 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 237.26
Formula C14H11N3O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 300586-90-7
PubChem ID 789882
InChI Key HWJRIFZDXJKJJN-UHFFFAOYSA-N
Smiles O=C(C3=CC=CC=C3)NC1=NC=C2C(C=CN2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 23.73 100
ethanol 23.73 100

Preparing Stock Solutions

The following data is based on the product molecular weight 237.26. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.21 mL 21.07 mL 42.15 mL
5 mM 0.84 mL 4.21 mL 8.43 mL
10 mM 0.42 mL 2.11 mL 4.21 mL
50 mM 0.08 mL 0.42 mL 0.84 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Li et al (2012) Identification of Oct4-activating compounds that enhance reprogramming efficiency. Proc.Natl.Acad.Sci.U S A 109 20853 PMID: 23213213


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Keywords: OAC-1, supplier, OAC1, iPSCs, reprogramming, factors, Oct4, activators, Sox2, Nanog, inducers, enhances, accelerates, Reprogramming, Other, Transcription, Factors, Reprogramming, Tocris Bioscience

Citations for OAC-1

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Stem Cells

Stem Cells Scientific Review

Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

Stem Cells

Stem Cells Poster

Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.