O8 OGG1 Inhibitor

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Cat.No. 6236 - O8 OGG1 Inhibitor | C9H6Cl2N2OS | CAS No. 350997-39-6
Description: Potent and selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor
Chemical Name: 3,4-Dichlorobenzo[b]thiophene-2-carbohydrazide
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity

Potent and selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor (IC50 = 0.2 μM in a gel based assay). Exhibits > 200-fold selectivity for OGG1 over other DNA glycosylases, NEIL1 and NTH1.

Compound Libraries

O8 OGG1 Inhibitor is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 261.13
Formula C9H6Cl2N2OS
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 350997-39-6
PubChem ID 874733
Smiles NNC(=O)C1=C(Cl)C2=C(Cl)C=CC=C2S1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 26.11 100

Preparing Stock Solutions

The following data is based on the product molecular weight 261.13. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.83 mL 19.15 mL 38.3 mL
5 mM 0.77 mL 3.83 mL 7.66 mL
10 mM 0.38 mL 1.91 mL 3.83 mL
50 mM 0.08 mL 0.38 mL 0.77 mL

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References are publications that support the biological activity of the product.

Donley et al (2015) Small molecule inhibitors of 8-oxoguanine DNA glycosylase-1 (OGG1). ACS Chem.Biol. 10 2334 PMID: 26218629

If you know of a relevant reference for O8 OGG1 Inhibitor, please let us know.

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