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Cat.No. 5639 - O4I1 | C16H15NO2 | CAS No. 175135-47-4
Description: Oct3/4 inducer
Chemical Name: 4-[(4-Methoxyphenyl)methoxy]benzeneacetonitrile
Purity: ≥99% (HPLC)

Biological Activity

Oct3/4 inducer. Increases Oct3/4 mRNA levels in HEK293 cells by 2.5- and 4-fold at 10 μM and 20 μM, respectively. Also increases expression of Oct3/4 in human adult and neonatal fibroblasts.

Compound Libraries

O4I1 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 253.3
Formula C16H15NO2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 175135-47-4
PubChem ID 2774690
Smiles N#CCC1=CC=C(OCC2=CC=C(OC)C=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 25.33 100
ethanol 1.27 5mM with sonication

Preparing Stock Solutions

The following data is based on the product molecular weight 253.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.95 mL 19.74 mL 39.48 mL
5 mM 0.79 mL 3.95 mL 7.9 mL
10 mM 0.39 mL 1.97 mL 3.95 mL
50 mM 0.08 mL 0.39 mL 0.79 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Cheng et al (2015) Identification of 2-[4-[(4-Methoxyphenyl)methoxy]-phenyl]acetonitrile and derivatives as potent Oct3/4 inducers. J.Med.Chem. 58 4976 PMID: 25898186

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Keywords: O4I1, supplier, induced, pluripotent, stem, cell, iPSCs, dedifferentiation, inducers, Oct3/4, reprogramming, Reprogramming, Tocris Bioscience

Citations for O4I1

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Literature in this Area

Stem Cells

Stem Cells Scientific Review

Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

Pathways for O4I1


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