Oct3/4 inducer. Increases Oct3/4 mRNA levels in HEK293 cells by 2.5- and 4-fold at 10 μM and 20 μM, respectively. Also increases expression of Oct3/4 in human adult and neonatal fibroblasts.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|ethanol||1.27||5mM with sonication|
Preparing Stock Solutions
The following data is based on the product molecular weight 253.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.95 mL||19.74 mL||39.48 mL|
|5 mM||0.79 mL||3.95 mL||7.9 mL|
|10 mM||0.39 mL||1.97 mL||3.95 mL|
|50 mM||0.08 mL||0.39 mL||0.79 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Cheng et al (2015) Identification of 2-[4-[(4-Methoxyphenyl)methoxy]-phenyl]acetonitrile and derivatives as potent Oct3/4 inducers. J.Med.Chem. 58 4976 PMID: 25898186
If you know of a relevant reference for O4I1, please let us know.
Keywords: O4I1, supplier, induced, pluripotent, stem, cell, iPSCs, dedifferentiation, inducers, Oct3/4, reprogramming, Reprogramming, Tocris Bioscience
Citations for O4I1
Citations are publications that use Tocris products.
Currently there are no citations for O4I1. Do you know of a great paper that uses O4I1 from Tocris? If so please let us know.
Literature in this Area
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.