Nω-Propyl-L-arginine hydrochloride
Biological Activity
Highly selective and potent inhibitor of nNOS (Ki = 57 nM). Displays 3158-fold and 149-fold selectivity over iNOS and eNOS respectively. Hypotensive in vivo.
Technical Data
| M. Wt | 252.74 |
| Formula | C9H20N4O2.HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 137361-05-8 |
| PubChem ID | 447180 |
| InChI Key | AOMXURITGZJPKB-ZETCQYMHSA-N |
| Smiles | N=C(NCCC[C@H](N)C(O)=O)NCCC.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 21.63 | 100 | |
| DMSO | 25.27 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 252.74. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.96 mL | 19.78 mL | 39.57 mL |
| 5 mM | 0.79 mL | 3.96 mL | 7.91 mL |
| 10 mM | 0.4 mL | 1.98 mL | 3.96 mL |
| 50 mM | 0.08 mL | 0.4 mL | 0.79 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the biological activity of the product.
Kakoki et al (2001) The influence of nitric oxide synthase 1 on blood flow and interstitial nitric oxide in the kidney. Am.J.Physiol.Regul.Integr.Comp.Physiol. 281 R91 PMID: 11404282
Zhang et al (1997) Potent and selective inhibition of neuronal nitric oxide synthase by Nω-propyl-L-arginine. J.Med.Chem. 40 3869 PMID: 9397167
If you know of a relevant reference for Nω-Propyl-L-arginine hydrochloride, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Nw-Propyl-L-arginine hydrochloride, Nw-Propyl-L-arginine hydrochloride supplier, selective, inhibitors, inhibits, nNOS, Nitric, Oxide, Signaling, Signalling, Neuronal, NO, Synthases, Nomega-Propyl-L-arginine, hydrochloride, 1200, Tocris Bioscience
4 Citations for Nω-Propyl-L-arginine hydrochloride
Citations are publications that use Tocris products. Selected citations for Nω-Propyl-L-arginine hydrochloride include:
Xu et al (2016) Cultured networks of excitatory projection neurons and inhibitory interneurons for studying human cortical neurotoxicity. Sci Transl Med 8 333ra48 PMID: 27053772
Lu et al (2015) Neuronal and Endothelial Nitric Oxide Synthases in the Paraventricular Nucleus Modulate Sympathetic Overdrive in Insulin-Resistant Rats. Diabetes 10 e0140762 PMID: 26485682
Mathison et al (2004) Effects of cannabinoid receptor-2 activation on accelerated gastrointestinal transit in lipopolysaccharide-treated rats. Br J Pharmacol 142 1247 PMID: 15249429
Slesinger (2001) Ion selectivity filter regulates local anesthetic inhibition of G-protein-gated inwardly rectifying K+ channels. Biophys J 80 707 PMID: 11159438
Do you know of a great paper that uses Nω-Propyl-L-arginine hydrochloride from Tocris? Please let us know.
Reviews for Nω-Propyl-L-arginine hydrochloride
There are currently no reviews for this product. Be the first to review Nω-Propyl-L-arginine hydrochloride and earn rewards!
Have you used Nω-Propyl-L-arginine hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cancer Research Product Guide
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
- Cancer Metabolism
- Epigenetics in Cancer
- Receptor Signaling
- Cell Cycle and DNA Damage Repair
- Angiogenesis
- Invasion and Metastasis
Neurodegeneration Product Guide
A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:
- Alzheimer's disease
- Parkinson's disease
- Huntington's disease
Schizophrenia Poster
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.
