Nω-Propyl-L-arginine hydrochloride

Description: Highly selective inhibitor of nNOS
Chemical Name: N5-[Imino(propylamino)methyl]-L-ornithine hydrochloride
Purity: ≥98% (HPLC)
Citations (4)
Literature (1)

Biological Activity for Nω-Propyl-L-arginine hydrochloride

Nω-Propyl-L-arginine hydrochloride is a highly selective and potent inhibitor of nNOS (Ki = 57 nM). Displays 3158-fold and 149-fold selectivity over iNOS and eNOS respectively. Hypotensive in vivo.

Technical Data for Nω-Propyl-L-arginine hydrochloride

M. Wt 252.74
Formula C9H20N4O2.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 2321366-46-3
PubChem ID 447180
Smiles N=C(NCCC[C@H](N)C(O)=O)NCCC.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Nω-Propyl-L-arginine hydrochloride

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References for Nω-Propyl-L-arginine hydrochloride

References are publications that support the biological activity of the product.

Kakoki et al (2001) The influence of nitric oxide synthase 1 on blood flow and interstitial nitric oxide in the kidney. Am.J.Physiol.Regul.Integr.Comp.Physiol. 281 R91 PMID: 11404282

Zhang et al (1997) Potent and selective inhibition of neuronal nitric oxide synthase by Nω-propyl-L-arginine. J.Med.Chem. 40 3869 PMID: 9397167

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4 Citations for Nω-Propyl-L-arginine hydrochloride

Citations are publications that use Tocris products. Selected citations for Nω-Propyl-L-arginine hydrochloride include:

Slesinger (2001) Ion selectivity filter regulates local anesthetic inhibition of G-protein-gated inwardly rectifying K+ channels. Biophys J 80 707 PMID: 11159438

Mathison et al (2004) Effects of cannabinoid receptor-2 activation on accelerated gastrointestinal transit in lipopolysaccharide-treated rats. Br J Pharmacol 142 1247 PMID: 15249429

Xu et al (2016) Cultured networks of excitatory projection neurons and inhibitory interneurons for studying human cortical neurotoxicity. Sci Transl Med 8 333ra48 PMID: 27053772

Lu et al (2015) Neuronal and Endothelial Nitric Oxide Synthases in the Paraventricular Nucleus Modulate Sympathetic Overdrive in Ins-Resistant Rats. Diabetes 10 e0140762 PMID: 26485682

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Literature in this Area

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