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Submit ReviewNω-Propyl-L-arginine hydrochloride
Description: Highly selective inhibitor of nNOS
Chemical Name: N5-[Imino(propylamino)methyl]-L-ornithine hydrochloride
Purity: ≥98% (HPLC)
Biological Activity
Highly selective and potent inhibitor of nNOS (Ki = 57 nM). Displays 3158-fold and 149-fold selectivity over iNOS and eNOS respectively. Hypotensive in vivo.
Technical Data
| M. Wt | 252.74 |
| Formula | C9H20N4O2.HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 2321366-46-3 |
| PubChem ID | 447180 |
| InChI Key | AOMXURITGZJPKB-ZETCQYMHSA-N |
| Smiles | N=C(NCCC[C@H](N)C(O)=O)NCCC.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 21.63 | 100 | |
| DMSO | 25.27 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 252.74. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.96 mL | 19.78 mL | 39.57 mL |
| 5 mM | 0.79 mL | 3.96 mL | 7.91 mL |
| 10 mM | 0.4 mL | 1.98 mL | 3.96 mL |
| 50 mM | 0.08 mL | 0.4 mL | 0.79 mL |
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References
References are publications that support the biological activity of the product.
Kakoki et al (2001) The influence of nitric oxide synthase 1 on blood flow and interstitial nitric oxide in the kidney. Am.J.Physiol.Regul.Integr.Comp.Physiol. 281 R91 PMID: 11404282
Zhang et al (1997) Potent and selective inhibition of neuronal nitric oxide synthase by Nω-propyl-L-arginine. J.Med.Chem. 40 3869 PMID: 9397167
If you know of a relevant reference for Nω-Propyl-L-arginine hydrochloride, please let us know.
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Keywords: Nw-Propyl-L-arginine hydrochloride, Nw-Propyl-L-arginine hydrochloride supplier, selective, inhibitors, inhibits, nNOS, Nitric, Oxide, Signaling, Signalling, Neuronal, NO, Synthases, Nomega-Propyl-L-arginine, hydrochloride, 137361-05-8, 1200, Tocris Bioscience
4 Citations for Nω-Propyl-L-arginine hydrochloride
Citations are publications that use Tocris products. Selected citations for Nω-Propyl-L-arginine hydrochloride include:
Mathison et al (2004) Effects of cannabinoid receptor-2 activation on accelerated gastrointestinal transit in lipopolysaccharide-treated rats. Br J Pharmacol 142 1247 PMID: 15249429
Slesinger (2001) Ion selectivity filter regulates local anesthetic inhibition of G-protein-gated inwardly rectifying K+ channels. Biophys J 80 707 PMID: 11159438
Xu et al (2016) Cultured networks of excitatory projection neurons and inhibitory interneurons for studying human cortical neurotoxicity. Sci Transl Med 8 333ra48 PMID: 27053772
Lu et al (2015) Neuronal and Endothelial Nitric Oxide Synthases in the Paraventricular Nucleus Modulate Sympathetic Overdrive in Ins-Resistant Rats. Diabetes 10 e0140762 PMID: 26485682
Do you know of a great paper that uses Nω-Propyl-L-arginine hydrochloride from Tocris? Please let us know.
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