Nω-Propyl-L-arginine hydrochloride

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Cat.No. 1200 - Nw-Propyl-L-arginine hydrochloride | C9H20N4O2.HCl | CAS No. 137361-05-8
Description: Highly selective inhibitor of nNOS
Chemical Name: N5-[Imino(propylamino)methyl]-L-ornithine hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (3)
Literature

Biological Activity

Highly selective and potent inhibitor of nNOS (Ki = 57 nM). Displays 3158-fold and 149-fold selectivity over iNOS and eNOS respectively. Hypotensive in vivo.

Technical Data

M. Wt 252.74
Formula C9H20N4O2.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 137361-05-8
PubChem ID 447180
InChI Key AOMXURITGZJPKB-ZETCQYMHSA-N
Smiles N=C(NCCC[C@H](N)C(O)=O)NCCC.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.27 100
water 21.63 100

Preparing Stock Solutions

The following data is based on the product molecular weight 252.74. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.96 mL 19.78 mL 39.57 mL
5 mM 0.79 mL 3.96 mL 7.91 mL
10 mM 0.4 mL 1.98 mL 3.96 mL
50 mM 0.08 mL 0.4 mL 0.79 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Kakoki et al (2001) The influence of nitric oxide synthase 1 on blood flow and interstitial nitric oxide in the kidney. Am.J.Physiol.Regul.Integr.Comp.Physiol. 281 R91 PMID: 11404282

Zhang et al (1997) Potent and selective inhibition of neuronal nitric oxide synthase by Nω-propyl-L-arginine. J.Med.Chem. 40 3869 PMID: 9397167


If you know of a relevant reference for Nω-Propyl-L-arginine hydrochloride, please let us know.

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Keywords: Nw-Propyl-L-arginine hydrochloride, supplier, selective, inhibitors, inhibits, nNOS, Nitric, Oxide, Signaling, Signalling, Neuronal, NO, Synthases, Nomega-Propyl-L-arginine, hydrochloride, nNOS, Tocris Bioscience

3 Citations for Nω-Propyl-L-arginine hydrochloride

Citations are publications that use Tocris products. Selected citations for Nω-Propyl-L-arginine hydrochloride include:

Mathison et al (2004) Effects of cannabinoid receptor-2 activation on accelerated gastrointestinal transit in lipopolysaccharide-treated rats. Br J Pharmacol 142 1247 PMID: 15249429

Slesinger (2001) Ion selectivity filter regulates local anesthetic inhibition of G-protein-gated inwardly rectifying K+ channels. Biophys J 80 707 PMID: 11159438

Lu et al (2015) Neuronal and Endothelial Nitric Oxide Synthases in the Paraventricular Nucleus Modulate Sympathetic Overdrive in Insulin-Resistant Rats. Diabetes 10 e0140762 PMID: 26485682


Do you know of a great paper that uses Nω-Propyl-L-arginine hydrochloride from Tocris? If so please let us know.

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