ARL 17477 dihydrochloride

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Cat.No. 3319 - ARL 17477 dihydrochloride | C20H20ClN3S.2HCl | CAS No. 866914-87-6
Description: Selective nNOS inhibitor
Chemical Name: N-[4-[2-[[(3-Chlorophenyl)methyl]amino]ethyl]phenyl]-2-thiophenecarboxamide dihydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (3)

Biological Activity

Selective neuronal nitrogen oxide synthase (nNOS) inhibitor (IC50 values are 1 and 17 μM for nNOS and endothelial NOS respectively). Reduces ischemic cell damage after middle cerebral artery (MCA) occlusion in rats. Displays a synergistic neuroprotective effect when combined with either an NMDA or AMPA receptor antagonist.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Compound Libraries

ARL 17477 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 442.83
Formula C20H20ClN3S.2HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 866914-87-6
PubChem ID 9824646
InChI Key SOXBYIKSUDXMIE-UHFFFAOYSA-N
Smiles ClC1=CC=CC(CNCCC2=CC=C(NC(C3=CC=CS3)=N)C=C2)=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 22.14 50
DMSO 44.28 100

Preparing Stock Solutions

The following data is based on the product molecular weight 442.83. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.26 mL 11.29 mL 22.58 mL
5 mM 0.45 mL 2.26 mL 4.52 mL
10 mM 0.23 mL 1.13 mL 2.26 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

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References

References are publications that support the biological activity of the product.

Hicks et al (1999) Synergistic neuroprotective effects by combining an NMDA or AMPA receptor antagonist with nitric oxide synthase inhibitors in global cerebral ischaemia. Eur.J.Pharmacol. 381 113 PMID: 10554878

O'Neill et al (2000) ARL 17477, a selective nitric oxide synthase inhibitor, with neuroprotective effects in animal models of global and focal cerebral ischaemia. Brain Res. 871 234 PMID: 10899290

Zhang et al (1996) ARL 17477, a potent and selective neuronal NOS inhibitor decreases infarct volume after transient middle cerebral artery occlusion in rats. J.Cereb.Flow Metab. 16 599


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Keywords: ARL 17477 dihydrochloride, ARL 17477 dihydrochloride supplier, neuronal, nitric, oxide, synthase, nNOS, inhibitors, inhibits, ARL17477, 3319, Tocris Bioscience

1 Citation for ARL 17477 dihydrochloride

Citations are publications that use Tocris products. Selected citations for ARL 17477 dihydrochloride include:

Grekov et al (2017) Calcium Ionophore, Calcimycin, Kills Leishmania Promastigotes by Activating Parasite Nitric Oxide Synthase. Biomed Res Int 2017 1309485 PMID: 29181385


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