NVP DPP 728 dihydrochloride

Discontinued Product

NVP DPP 728 dihydrochloride (Cat. No. 3506) has been withdrawn from sale for commercial reasons.
Cat.No. 3506 - NVP DPP 728 dihydrochloride | C15H18N6O.2HCl | CAS No. 207556-62-5
Description: Potent, orally active dipeptidyl peptidase IV (DPP-IV) inhibitor
Chemical Name: 6-[[2-[[2-(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethyl]amino]ethyl]amino-3-pyridinecarbononitrile dihydrochloride
Purity: ≥97% (HPLC)
Datasheet
Citations (1)
Reviews

Biological Activity

Potent, orally active dipeptidyl peptidase (DPP)-IV inhibitor (Ki = 11 nM, IC50 = 14 nM) that displays > 15 000-fold selectivity over DPP-II and a range of proline-cleaving proteases. Exhibits antidiabetic activity in vivo; improves glucose tolerance, increases glucagon-like peptide 1 (GLP-1) and insulin levels, augments insulin secretion and GLUT2 levels, and reduces (preserves) islet size.

Compound Libraries

NVP DPP 728 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 371.27
Formula C15H18N6O.2HCl
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 207556-62-5
PubChem ID 9799555
InChI Key VNACOBVZDCLAEV-GXKRWWSZSA-N
Smiles O=C(N2CCC[C@H]2C#N)CNCCNC1=NC=C(C#N)C=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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1 Citation for NVP DPP 728 dihydrochloride

Citations are publications that use Tocris products. Selected citations for NVP DPP 728 dihydrochloride include:

Inoue et al (2012) Dipeptidyl peptidase IV inhibition potentiates amino acid- and bile acid-induced bicarbonate secretion in rat duodenum. Stem Cell Reports 303 G810 PMID: 22821947


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