NVP DPP 728 dihydrochloride
Potent, orally active dipeptidyl peptidase (DPP)-IV inhibitor (Ki = 11 nM, IC50 = 14 nM) that displays > 15 000-fold selectivity over DPP-II and a range of proline-cleaving proteases. Exhibits antidiabetic activity in vivo; improves glucose tolerance, increases glucagon-like peptide 1 (GLP-1) and insulin levels, augments insulin secretion and GLUT2 levels, and reduces (preserves) islet size.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 371.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.69 mL||13.47 mL||26.93 mL|
|5 mM||0.54 mL||2.69 mL||5.39 mL|
|10 mM||0.27 mL||1.35 mL||2.69 mL|
|50 mM||0.05 mL||0.27 mL||0.54 mL|
References are publications that support the biological activity of the product.
Hughes et al (1999) NVP-DPP728 (1-[[[2-[(5-cyanopyridin-2-yl)amino]ethyl]amino]acetyl]-2-cyano-(S)-pyrrolidine), a slow-binding inhibitor of dipeptidyl peptidase IV. Biochemistry 38 11597 PMID: 10512614
Reimer et al (2002) Long-term inhibition of dipeptidyl peptidase IV improves glucose tolerance and preserves islet function in mice. Eur.J.Endocrinol. 146 717 PMID: 11980629
Mitani et al (2002) Dipeptidyl peptidase IV inhibitor NVP-DPP728 ameliorates early insulin response and glucose tolerance in aged rats but not in aged Fischer 344 rats lacking its enzyme activity. Jpn.J.Pharmacol. 88 451 PMID: 12046989
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Keywords: NVP DPP 728 dihydrochloride, NVP DPP 728 dihydrochloride supplier, Potent, orally, active, DPP-IV, inhibitors, inhibits, Dipeptidyl, Peptidase, IV, Proteinases, Proteases, NVPDPP728, dihydrochloride, (DPP-IV), Glucose, Transporters, 3506, Tocris Bioscience
1 Citation for NVP DPP 728 dihydrochloride
Citations are publications that use Tocris products. Selected citations for NVP DPP 728 dihydrochloride include:
Inoue et al (2012) Dipeptidyl peptidase IV inhibition potentiates amino acid- and bile acid-induced bicarbonate secretion in rat duodenum. Stem Cell Reports 303 G810 PMID: 22821947
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