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Biological Activity for NSC 95397
NSC 95397 is a potent and selective irreversible inhibitor of Cdc25 dual specificity phosphatases (Ki values are 32, 96 and 40 nM for inhibition of Cdc25A, -B and -C respectively). Displays 125 - 180-fold selectivity over VH1-related dual-specificity phosphatase and protein tyrosine phosphatase 1b. Inhibits carcinoma cell growth and blocks G2/M phase transition in vitro.
Technical Data for NSC 95397
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for NSC 95397
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for NSC 95397
The following data is based on the product molecular weight 310.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||6.44 mL||32.22 mL||64.44 mL|
|2.5 mM||1.29 mL||6.44 mL||12.89 mL|
|5 mM||0.64 mL||3.22 mL||6.44 mL|
|25 mM||0.13 mL||0.64 mL||1.29 mL|
References for NSC 95397
References are publications that support the biological activity of the product.
Han et al (2004) NAD(P)H:Quinone oxidoreductase-1-dependent and -independent cytotoxicity of potent quinone Cdc25 phosphatase inhibitors. J.Pharmacol.Exp.Ther. 309 64 PMID: 14718602
Lazo et al (2002) Identification of a potent and selective pharmacophore for Cdc25 dual specificity phosphatase inhibitors. Mol.Pharmacol. 61 720 PMID: 11901209
Melchheier et al (2005) Quinone-induced Cdc25A inhibition causes ERK-dependent connexin phosphorylation. Biochem.Biophys.Res.Commun. 327 1016 PMID: 15652497
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Keywords: NSC 95397, NSC 95397 supplier, Selective, Cdc25, dual, specificity, phosphatases, inhibitors, inhibits, NSC95397, Phosphatase, 1547, Tocris Bioscience
1 Citation for NSC 95397
Citations are publications that use Tocris products. Selected citations for NSC 95397 include:
Dulyaninova et al (2011) Cysteine 81 is critical for the interaction of S100A4 and myosin-IIA. Biochemistry 50 7218 PMID: 21749055
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Literature in this Area
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Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 170 products, including research tools for:
- Cell Cycle and Mitosis
- DNA Damage Repair
- Targeted Protein Degradation
- Ubiquitin Proteasome Pathway
- Chemotherapy Targets
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.