NSC 87877

Pricing Availability   Qty
Cat.No. 2613 - NSC 87877 | C19H13N3O7S2 | CAS No. 56990-57-9
Description: Potent inhibitor of shp2 and shp1 PTP
Chemical Name: 8-Hydroxy-7-[(6-sulfo-2-naphthyl)azo]-5-quinolinesulfonic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (6)
Reviews
Literature

Biological Activity

Potent inhibitor of shp2 and shp1 protein tyrosine phosphatases (PTP) (IC50 values are 0.318, 0.355, 1.691, 7.745, 65.617, 84.473 and 150.930 μM for shp2, shp1, PTP1B, HePTP, DEP1, CD45 and LAR respectively). Inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation.

Technical Data

M. Wt 459.45
Formula C19H13N3O7S2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 56990-57-9
PubChem ID 5459322
InChI Key BIQBDHSYQMHHPU-CJLVFECKSA-N
Smiles OC2=C(/N=N/C3=CC=C(C=C(S(=O)(O)=O)C=C4)C4=C3)C=C(S(=O)(O)=O)C1=CC=CN=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 22.97 50
DMSO 9.19 20

Preparing Stock Solutions

The following data is based on the product molecular weight 459.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.35 mL 21.77 mL 43.53 mL
2.5 mM 0.87 mL 4.35 mL 8.71 mL
5 mM 0.44 mL 2.18 mL 4.35 mL
25 mM 0.09 mL 0.44 mL 0.87 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Chen et al (2006) Discovery of a novel shp2 protein tyrosine phosphatase inhibitor. Mol.Pharmacol. 70 562 PMID: 16717135

Zhao et al (2007) Regulation of ACh receptor clustering by the tyrosine phosphatase Shp2. Dev.Neurobiol. 67 1789 PMID: 17659592

Redonde et al (2007) hTRPC1-associated α-actinin, and not hTRPC1 itself, is tyrosine phosphorylated during human platelet activation. J.Thromb.Haemost. 5 2476 PMID: 17892531


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View all Protein Tyrosine Phosphatases Inhibitors

Keywords: NSC 87877, NSC 87877 supplier, Potent, inhibitors, inhibits, shp2, shp1, PTP, Protein, Tyrosine, Phosphatases, NSC87877, 2613, Tocris Bioscience

6 Citations for NSC 87877

Citations are publications that use Tocris products. Selected citations for NSC 87877 include:

Quintanar-Audelo et al (2011) Sprouty-related Ena/vasodilator-stimulated phosphoprotein homology 1-domain-containing protein (SPRED1), a tyrosine-protein phosphatase non-receptor type 11 (SHP2) substrate in the Ras/extracellular signal-regulated kinase (ERK) pathway. J Biol Chem 286 23102 PMID: 21531714

Fragale et al (2011) Critical role of IRF-8 in negative regulation of TLR3 expression by Src homology 2 domain-containing protein tyrosine phosphatase-2 activity in human myeloid dendritic cells. J Immunol 186 1951 PMID: 21220691

Abeyweera et al (2011) Inhibitory signaling blocks activating receptor clustering and induces cytoskeletal retraction in natural killer cells. J Cell Biol 192 675 PMID: 21339333

Pinzon-Guzman et al (2015) Regulation of rod photoreceptor differentiation by STAT3 is controlled by a tyrosine phosphatase. Int J Cancer 55 152 PMID: 25108518

Taylor et al (2016) Glycogen Synthase Kinase 3 Inactivation Drives T-bet-Mediated Downregulation of Co-receptor PD-1 to Enhance CD8(+) Cytolytic T Cell Responses. Immunity 44 274 PMID: 26885856

Zhang et al (2016) Increased Activity of Src Homology 2 Domain Containing Phosphotyrosine Phosphatase 2 (Shp2) Regulates Activity-dependent AMPA Receptor Trafficking. J Biol Chem 291 18856 PMID: 27417137


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Cancer

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