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Description: Potent inhibitor of shp2 and shp1 PTP
Chemical Name: 8-Hydroxy-7-[(6-sulfo-2-naphthyl)azo]-5-quinolinesulfonic acid
Purity: ≥98% (HPLC)
Biological Activity for NSC 87877
NSC 87877 is a potent inhibitor of shp2 and shp1 protein tyrosine phosphatases (PTP) (IC50 values are 0.318, 0.355, 1.691, 7.745, 65.617, 84.473 and 150.930 μM for shp2, shp1, PTP1B, HePTP, DEP1, CD45 and LAR respectively). Inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation.
Technical Data for NSC 87877
| M. Wt | 459.45 |
| Formula | C19H13N3O7S2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 56990-57-9 |
| PubChem ID | 5459322 |
| InChI Key | BIQBDHSYQMHHPU-CJLVFECKSA-N |
| Smiles | OC2=C(/N=N/C3=CC=C(C=C(S(=O)(O)=O)C=C4)C4=C3)C=C(S(=O)(O)=O)C1=CC=CN=C12 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for NSC 87877
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 22.97 | 50 | |
| DMSO | 9.19 | 20 |
Preparing Stock Solutions for NSC 87877
The following data is based on the product molecular weight 459.45. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.35 mL | 21.77 mL | 43.53 mL |
| 2.5 mM | 0.87 mL | 4.35 mL | 8.71 mL |
| 5 mM | 0.44 mL | 2.18 mL | 4.35 mL |
| 25 mM | 0.09 mL | 0.44 mL | 0.87 mL |
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Product Datasheets for NSC 87877
References for NSC 87877
References are publications that support the biological activity of the product.
Chen et al (2006) Discovery of a novel shp2 protein tyrosine phosphatase inhibitor. Mol.Pharmacol. 70 562 PMID: 16717135
Zhao et al (2007) Regulation of ACh receptor clustering by the tyrosine phosphatase Shp2. Dev.Neurobiol. 67 1789 PMID: 17659592
Redonde et al (2007) hTRPC1-associated α-actinin, and not hTRPC1 itself, is tyrosine phosphorylated during human platelet activation. J.Thromb.Haemost. 5 2476 PMID: 17892531
If you know of a relevant reference for NSC 87877, please let us know.
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Keywords: NSC 87877, NSC 87877 supplier, Potent, inhibitors, inhibits, shp2, shp1, PTP, Protein, Tyrosine, Phosphatases, NSC87877, 2613, Tocris Bioscience
8 Citations for NSC 87877
Citations are publications that use Tocris products. Selected citations for NSC 87877 include:
Kim et al (2017) Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO Mutation. Cell 168 1053 PMID: 28283061
Zhang and Lu (2017) Src homology 2 domain-containing phosphotyrosine phosphatase 2 (Shp2) controls surface GluA1 protein in synaptic homeostasis. J Biol Chem 292 15481 PMID: 28768764
Quintanar-Audelo et al (2011) Sprouty-related Ena/vasodilator-stimulated phosphoprotein homology 1-domain-containing protein (SPRED1), a tyrosine-protein phosphatase non-receptor type 11 (SHP2) substrate in the Ras/extracellular signal-regulated kinase (ERK) pathway. J Biol Chem 286 23102 PMID: 21531714
Fragale et al (2011) Critical role of IRF-8 in negative regulation of TLR3 expression by Src homology 2 domain-containing protein tyrosine phosphatase-2 activity in human myeloid dendritic cells. J Immunol 186 1951 PMID: 21220691
Abeyweera et al (2011) Inhibitory signaling blocks activating receptor clustering and induces cytoskeletal retraction in natural killer cells. J Cell Biol 192 675 PMID: 21339333
Taylor et al (2016) Glycogen Synthase Kinase 3 Inactivation Drives T-bet-Mediated Downregulation of Co-receptor PD-1 to Enhance CD8(+) Cytolytic T Cell Responses. Immunity 44 274 PMID: 26885856
Zhang et al (2016) Increased Activity of Src Homology 2 Domain Containing Phosphotyrosine Phosphatase 2 (Shp2) Regulates Activity-dependent AMPA Receptor Trafficking. J Biol Chem 291 18856 PMID: 27417137
Pinzon-Guzman et al (2015) Regulation of rod photoreceptor differentiation by STAT3 is controlled by a tyrosine phosphatase. Int J Cancer 55 152 PMID: 25108518
Do you know of a great paper that uses NSC 87877 from Tocris? Please let us know.
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