NSC 87877

Pricing Availability   Qty
Description: Potent inhibitor of shp2 and shp1 PTP
Chemical Name: 8-Hydroxy-7-[(6-sulfo-2-naphthyl)azo]-5-quinolinesulfonic acid
Purity: ≥98% (HPLC)
Citations (8)

Biological Activity for NSC 87877

NSC 87877 is a potent inhibitor of shp2 and shp1 protein tyrosine phosphatases (PTP) (IC50 values are 0.318, 0.355, 1.691, 7.745, 65.617, 84.473 and 150.930 μM for shp2, shp1, PTP1B, HePTP, DEP1, CD45 and LAR respectively). Inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation.

Technical Data for NSC 87877

M. Wt 459.45
Formula C19H13N3O7S2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 56990-57-9
PubChem ID 5459322
Smiles OC2=C(/N=N/C3=CC=C(C=C(S(=O)(O)=O)C=C4)C4=C3)C=C(S(=O)(O)=O)C1=CC=CN=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NSC 87877

Solvent Max Conc. mg/mL Max Conc. mM
water 22.97 50
DMSO 9.19 20

Preparing Stock Solutions for NSC 87877

The following data is based on the product molecular weight 459.45. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.35 mL 21.77 mL 43.53 mL
2.5 mM 0.87 mL 4.35 mL 8.71 mL
5 mM 0.44 mL 2.18 mL 4.35 mL
25 mM 0.09 mL 0.44 mL 0.87 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for NSC 87877

Certificate of Analysis / Product Datasheet
Select another batch:

References for NSC 87877

References are publications that support the biological activity of the product.

Chen et al (2006) Discovery of a novel shp2 protein tyrosine phosphatase inhibitor. Mol.Pharmacol. 70 562 PMID: 16717135

Zhao et al (2007) Regulation of ACh receptor clustering by the tyrosine phosphatase Shp2. Dev.Neurobiol. 67 1789 PMID: 17659592

Redonde et al (2007) hTRPC1-associated α-actinin, and not hTRPC1 itself, is tyrosine phosphorylated during human platelet activation. J.Thromb.Haemost. 5 2476 PMID: 17892531

If you know of a relevant reference for NSC 87877, please let us know.

View Related Products by Product Action

View all Protein Tyrosine Phosphatases Inhibitors

Keywords: NSC 87877, NSC 87877 supplier, Potent, inhibitors, inhibits, shp2, shp1, PTP, Protein, Tyrosine, Phosphatases, NSC87877, 2613, Tocris Bioscience

8 Citations for NSC 87877

Citations are publications that use Tocris products. Selected citations for NSC 87877 include:

Pinzon-Guzman et al (2015) Regulation of rod photoreceptor differentiation by STAT3 is controlled by a tyrosine phosphatase. Int J Cancer 55 152 PMID: 25108518

Kim et al (2017) Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO Mutation. Cell 168 1053 PMID: 28283061

Zhang and Lu (2017) Src homology 2 domain-containing phosphotyrosine phosphatase 2 (Shp2) controls surface GluA1 protein in synaptic homeostasis. J Biol Chem 292 15481 PMID: 28768764

Taylor et al (2016) Glycogen Synthase Kinase 3 Inactivation Drives T-bet-Mediated Downregulation of Co-receptor PD-1 to Enhance CD8(+) Cytolytic T Cell Responses. Immunity 44 274 PMID: 26885856

Do you know of a great paper that uses NSC 87877 from Tocris? Please let us know.

Reviews for NSC 87877

There are currently no reviews for this product. Be the first to review NSC 87877 and earn rewards!

Have you used NSC 87877?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review