NSC 693868

Discontinued Product

NSC 693868 (Cat. No. 1937) has been withdrawn from sale for commercial reasons.
Description: Cdk inhibitor; also inhibits GSK-3
Chemical Name: 1H-Pyrazolo[3,4-b]quinoxalin-3-amine
Purity: ≥99% (HPLC)
Literature (2)

Biological Activity for NSC 693868

Cyclin-dependent kinase (cdk) inhibitor (reported IC50 values are 0.4, 0.6, 4.4 - 5.6 μM for cdk5, cdk1 and cdk2, respectively). Also inhibits GSK-3 (IC50 = 1 uM).

Technical Data for NSC 693868

M. Wt 185.19
Formula C9H7N5
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 40254-90-8
PubChem ID 438981
Smiles NC1=NN=C2NC3=CC=CC=C3N=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for NSC 693868

Certificate of Analysis / Product Datasheet
Select another batch:

References for NSC 693868

References are publications that support the biological activity of the product.

Ortega et al (2002) Pyrazolo[3,4-b]quinoxalines. A new class of cyclin-dependent kinases inhibitors. Bioorg.Med.Chem.Lett. 10 2177 PMID: 11983514

Monge et al (1995) 3-Amino-2-quinoxalinecarbonitrile. New fused quinoxalines with potential cytotoxic activity. J.Heterocycl.Chem. 31 1135

Jorda et al (2018) How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 61 9105 PMID: 30234987

View Related Products by Product Action

View all Cyclin-Dependent Kinase Inhibitors

Keywords: NSC 693868, NSC 693868 supplier, GSK-3, inhibitors, inhibits, cdks, GSK, Glycogen, Synthase, Kinases, 3, Cyclin-Dependent, Protein, Carbohydrate, Metabolism, NSC693868, Cyclin-dependent, Kinase, 1937, Tocris Bioscience

Citations for NSC 693868

Citations are publications that use Tocris products.

Currently there are no citations for NSC 693868.

Reviews for NSC 693868

There are currently no reviews for this product. Be the first to review NSC 693868 and earn rewards!

Have you used NSC 693868?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:

  • Cell Cycle and Mitosis
  • DNA Damage Repair
  • Targeted Protein Degradation
  • Ubiquitin Proteasome Pathway
  • Chemotherapy Targets
Cell Cycle & DNA Damage Repair Poster

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.