NSC 687852

Pricing Availability Delivery Time Qty
Cat.No. 4566 - NSC 687852 | C22H17N3O6 | CAS No. 1009817-63-3
Description: Inhibitor of UCHL5 and USP14
Alternative Names: b-AP15
Chemical Name: 3,5-Bis[(4-nitrophenyl)methylene]-1-(1-oxo-2-propene-1-yl)-4-piperidone
Purity: ≥97% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Inhibitor of 19S regulatory particle associated deubiquitinating enzymes (DUBs), UCHL5 and USP14. Shows minimal inhibition of UCHL-1, UCHL-3, USP2, USP7, USP, BAP1 and proteasome activity. Induces apoptosis by cathepsin D-dependent caspase-cleavage (IC50 = 0.5 μM). Displays antitumor activity in vivo.

Technical Data

M. Wt 419.39
Formula C22H17N3O6
Storage Store at +4°C
Purity ≥97% (HPLC)
CAS Number 1009817-63-3
PubChem ID 5351435
InChI Key GFARQYQBWJLZMW-JYFOCSDGSA-N
Smiles O=C(/C(CN(C(C=C)=O)C3)=C/C2=CC=C([N+]([O-])=O)C=C2)/C3=C/C1=CC=C([N+]([O-])=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.94 100

Preparing Stock Solutions

The following data is based on the product molecular weight 419.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.38 mL 11.92 mL 23.84 mL
5 mM 0.48 mL 2.38 mL 4.77 mL
10 mM 0.24 mL 1.19 mL 2.38 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Berndtsson et al (2009) Induction of the lysosomal apoptosis pathway by inhibitors of the ubiquitin-proteasome system. Int.J.Cancer 124 1463 PMID: 19089926

D'Arcy et al (2011) Inhibition of proteasome deubiquitinating activity as a new cancer therapy. Nat.Med. 17 1636 PMID: 22057347


If you know of a relevant reference for NSC 687852, please let us know.

View Related Products by Product Action

View all Deubiquitinating Enzyme Inhibitors

Keywords: NSC687852 19S regulatory particle associated deubiquitylating enzymes DUBs apoptosis UCHL5 USP14 cathepsin D dependent caspase cleavage antitumor b-AP15 Deubiquitinating Enzymes

Citations for NSC 687852

Citations are publications that use Tocris products.

Currently there are no citations for NSC 687852. Do you know of a great paper that uses NSC 687852 from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

Pathways for NSC 687852

Protocols

TODO: Add Protocols