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Potent MDM2 inhibitor (Ki = 120 nM) which disrupts MDM2-p53 interaction and activates p53 function. Induces p21, p53 and MDM2 accumulation in human colon cancer cells in vitro.
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The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Lu et al (2006) Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening strategy. J.Med.Chem. 49 3759 PMID: 16789731
Shangary and Shaomeng (2009) Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy. Ann.Rev.Pharmacol.Toxicol. 49 223
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Keywords: NSC 66811, NSC 66811 supplier, MDM2, antagonists, Disrupts, MDM2-p53, interaction, Transcription, Factors, NSC66811, p53, Ubiquitin, E3, Ligases, 2936, Tocris Bioscience
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