NSC 66811

Discontinued Product

NSC 66811 (Cat. No. 2936) has been withdrawn from sale for commercial reasons.
Cat.No. 2936 - NSC 66811 | C23H20N2O | CAS No. 6964-62-1
Description: MDM2 antagonist. Disrupts MDM2-p53 interaction
Chemical Name: 2-Methyl-7-[Phenyl(phenylamino)methyl]-8-quinolinol
Purity: ≥97% (HPLC)
Literature (3)

Biological Activity

Potent MDM2 inhibitor (Ki = 120 nM) which disrupts MDM2-p53 interaction and activates p53 function. Induces p21, p53 and MDM2 accumulation in human colon cancer cells in vitro.

Technical Data

M. Wt 340.42
Formula C23H20N2O
Storage Store at +4°C
Purity ≥97% (HPLC)
CAS Number 6964-62-1
PubChem ID 248986
Smiles CC2=NC1=C(O)C(C(NC4=CC=CC=C4)C3=CC=CC=C3)=CC=C1C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.


References are publications that support the biological activity of the product.

Lu et al (2006) Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening strategy. J.Med.Chem. 49 3759 PMID: 16789731

Shangary and Shaomeng (2009) Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy. Ann.Rev.Pharmacol.Toxicol. 49 223

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Keywords: NSC 66811, NSC 66811 supplier, MDM2, antagonists, Disrupts, MDM2-p53, interaction, Transcription, Factors, NSC66811, p53, Ubiquitin, E3, Ligases, 2936, Tocris Bioscience

Citations for NSC 66811

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Currently there are no citations for NSC 66811.

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Literature in this Area

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