NSC 66811

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Cat.No. 2936 - NSC 66811 | C23H20N2O | CAS No. 6964-62-1
Description: MDM2 antagonist. Disrupts MDM2-p53 interaction
Chemical Name: 2-Methyl-7-[Phenyl(phenylamino)methyl]-8-quinolinol
Purity: ≥97% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent MDM2 inhibitor (Ki = 120 nM) which disrupts MDM2-p53 interaction and activates p53 function. Induces p21, p53 and MDM2 accumulation in human colon cancer cells in vitro.

Technical Data

M. Wt 340.42
Formula C23H20N2O
Storage Store at +4°C
Purity ≥97% (HPLC)
CAS Number 6964-62-1
PubChem ID 248986
InChI Key WEENRMPCSWFMTE-UHFFFAOYSA-N
Smiles CC2=NC1=C(O)C(C(NC4=CC=CC=C4)C3=CC=CC=C3)=CC=C1C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 34.04 100

Preparing Stock Solutions

The following data is based on the product molecular weight 340.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.94 mL 14.69 mL 29.38 mL
5 mM 0.59 mL 2.94 mL 5.88 mL
10 mM 0.29 mL 1.47 mL 2.94 mL
50 mM 0.06 mL 0.29 mL 0.59 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Lu et al (2006) Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening strategy. J.Med.Chem. 49 3759 PMID: 16789731

Shangary and Shaomeng (2009) Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy. Ann.Rev.Pharmacol.Toxicol. 49 223 PMID:


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Keywords: NSC 66811, supplier, MDM2, antagonists, Disrupts, MDM2-p53, interaction, Transcription, Factors, NSC66811, Ubiquitin, E3, Ligases, Tocris Bioscience

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Programmed Cell Death

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for NSC 66811

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