NS 9283

Pricing Availability   Qty
Description: Positive allosteric modulator of α4β2 nAChRs
Chemical Name: 3-[3-(3-Pyridinyl)-1,2,4-oxadiazol-5-yl]benzonitrile
Purity: ≥99% (HPLC)
Citations (1)
Literature (2)

Biological Activity for NS 9283

NS 9283 is a positive allosteric modulator of α4β2 receptor; increases the potency of Ach-evoked currents ~60 fold without affecting the maximum efficacy (HEK293-hα4β2 cells). Reduces the rate of recovery from desensitization and slows the rate of deactivation. Displays a synergistic effect on the Emax when given with NS206 at 3α:2β receptors.

Compound Libraries for NS 9283

NS 9283 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for NS 9283

M. Wt 248.24
Formula C14H8N4O
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 913830-15-6
PubChem ID 11998180
Smiles N#CC1=CC(C2=NC(C3=CN=CC=C3)=NO2)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NS 9283

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 12.41 50
1eq. HCl 4.96 20

Preparing Stock Solutions for NS 9283

The following data is based on the product molecular weight 248.24. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 8.06 mL 40.28 mL 80.57 mL
2.5 mM 1.61 mL 8.06 mL 16.11 mL
5 mM 0.81 mL 4.03 mL 8.06 mL
25 mM 0.16 mL 0.81 mL 1.61 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for NS 9283

References are publications that support the biological activity of the product.

Grupe et al (2013) Unravelling the mechanism of action of NS9283, a positive allosteric modulator of (α4)3(β2)2 nicotinic ACh receptors. Br.J.Pharmacol. 168 2000 PMID: 23278456

Mohler et al (2014) Discriminative-stimulus effects of NS9283, a nicotinic α4β2* positive allosteric modulator, in nicotine-discriminating rats. Psychopharmacology (Berl). 231 67 PMID: 23925734

Olsen et al (2013) Two distinct allosteric binding sites at α4β2 nicotinic acetylcholine receptors revealed by NS206 and NS9283 give unique insights to binding activity-associated linkage at Cys-loop receptor J.Biol.Chem. 288 35997 PMID: 24169695

If you know of a relevant reference for NS 9283, please let us know.

View Related Products by Product Action

View all Nicotinic (α4β2) Receptor Modulators

Keywords: NS 9283, NS 9283 supplier, NS9283, Acetylcholine, nicotinic, ⓮⓶, receptors, positive, allosteric, modulators, PAM, Nicotinic, (a4b2), Receptors, 5112, Tocris Bioscience

1 Citation for NS 9283

Citations are publications that use Tocris products. Selected citations for NS 9283 include:

Wang et al (2017) Unraveling amino acid residues critical for allosteric potentiation of (α4)3(β2)2-type nicotinic acetylcholine receptor responses. J.Med.Chem. 292 9988 PMID: 28446611

Do you know of a great paper that uses NS 9283 from Tocris? Please let us know.

Reviews for NS 9283

There are currently no reviews for this product. Be the first to review NS 9283 and earn rewards!

Have you used NS 9283?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Nicotinic ACh Receptors Scientific Review

Nicotinic ACh Receptors Scientific Review

Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.

Alzheimer's Disease Poster

Alzheimer's Disease Poster

Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.