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Submit Review6140 has been discontinued.
α7 nAChR agonist at human and rat receptors (EC50 of 0.72 and 0.88 μM respectively). Stimulates α7 nAChR induced ERK phosphorylation in vitro and enhances avoidance learning in mice. Also evokes Ca2+ transients in IMR-32 neuroblastoma cells, with similar potency to PNU 282987 (Cat.No. 2303).
M. Wt | 306.79 |
Formula | C15H18N4O.HCl |
Storage | Store at +4°C |
Purity | ≥98% (HPLC) |
PubChem ID | 132470911 |
InChI Key | SLZGVSXFCPFOOO-UHFFFAOYSA-N |
Smiles | N12CCC(N(C3=NN=C(C4=CC=CC=C4)O3)CC2)CC1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Kouhen et al (2009) Pharmacology of α7 nicotinic acetylcholine receptor mediated extracellular signal-regulatedkinase signalling in PC12 cells. Br.J.Pharmacol. 156 638 PMID: 19226255
Briggs et al (2009) Role of channel activation in cognitive enhancement mediated by α7 nicotinic acetylcholine receptors. Br.J.Pharmacol. 158 1486 PMID: 19845675
Ween et al (2010) α3* and α7 nAChR-mediated Ca2+ transient generation in IMR-32 neuroblastoma cells. Neurochem.Int. 57 269 PMID: 20558224
Keywords: NS 6784 hydrochloride, NS 6784 hydrochloride supplier, NS6784, HCl, 677723-97-6, alpha, 7, nicotinic, acetylcholine, receptors, activators, activates, agonists, nAChRs, Nicotinic, (a7), Receptors, 6140, Tocris Bioscience
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