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Submit ReviewNS 6784 hydrochloride
Discontinued Product
NS 6784 hydrochloride (Cat. No. 6140) has been withdrawn from sale for commercial reasons.
Description: α7 nAChR agonist
Chemical Name: 4-(5-Phenyl-1,3,4-oxadiazol-2-yl)-1,4-diazabicyclo[3.2.2]nonane hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for NS 6784 hydrochloride
α7 nAChR agonist at human and rat receptors (EC50 of 0.72 and 0.88 μM respectively). Stimulates α7 nAChR induced ERK phosphorylation in vitro and enhances avoidance learning in mice. Also evokes Ca2+ transients in IMR-32 neuroblastoma cells, with similar potency to PNU 282987 (Cat.No. 2303).
Technical Data for NS 6784 hydrochloride
| M. Wt | 306.79 |
| Formula | C15H18N4O.HCl |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| PubChem ID | 132470911 |
| InChI Key | SLZGVSXFCPFOOO-UHFFFAOYSA-N |
| Smiles | N12CCC(N(C3=NN=C(C4=CC=CC=C4)O3)CC2)CC1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for NS 6784 hydrochloride
References for NS 6784 hydrochloride
References are publications that support the biological activity of the product.
Kouhen et al (2009) Pharmacology of α7 nicotinic acetylcholine receptor mediated extracellular signal-regulatedkinase signalling in PC12 cells. Br.J.Pharmacol. 156 638 PMID: 19226255
Briggs et al (2009) Role of channel activation in cognitive enhancement mediated by α7 nicotinic acetylcholine receptors. Br.J.Pharmacol. 158 1486 PMID: 19845675
Ween et al (2010) α3* and α7 nAChR-mediated Ca2+ transient generation in IMR-32 neuroblastoma cells. Neurochem.Int. 57 269 PMID: 20558224
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Keywords: NS 6784 hydrochloride, NS 6784 hydrochloride supplier, NS6784, HCl, 677723-97-6, alpha, 7, nicotinic, acetylcholine, receptors, activators, activates, agonists, nAChRs, Nicotinic, (a7), Receptors, 6140, Tocris Bioscience
Citations for NS 6784 hydrochloride
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Currently there are no citations for NS 6784 hydrochloride.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
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