NS 6784 hydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 6140 - NS 6784 hydrochloride | C15H18N4O.HCl
Description: α7 nAChR agonist
Chemical Name: 4-(5-Phenyl-1,3,4-oxadiazol-2-yl)-1,4-diazabicyclo[3.2.2]nonane hydrochloride
Purity: ≥98% (HPLC)

Biological Activity

α7 nAChR agonist at human and rat receptors (EC50 of 0.72 and 0.88 μM respectively). Stimulates α7 nAChR induced ERK phosphorylation in vitro and enhances avoidance learning in mice. Also evokes Ca2+ transients in IMR-32 neuroblastoma cells, with similar potency to PNU 282987 (Cat.No.2303).

Technical Data

M. Wt 306.79
Formula C15H18N4O.HCl
Storage Store at +4°C
Purity ≥98% (HPLC)
Smiles N12CCC(N(C3=NN=C(C4=CC=CC=C4)O3)CC2)CC1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 6.14 20
water 30.68 100

Preparing Stock Solutions

The following data is based on the product molecular weight 306.79. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.26 mL 16.3 mL 32.6 mL
5 mM 0.65 mL 3.26 mL 6.52 mL
10 mM 0.33 mL 1.63 mL 3.26 mL
50 mM 0.07 mL 0.33 mL 0.65 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Kouhen et al (2009) Pharmacology of α7 nicotinic acetylcholine receptor mediated extracellular signal-regulatedkinase signalling in PC12 cells. Br.J.Pharmacol. 156 638 PMID: 19226255

Briggs et al (2009) Role of channel activation in cognitive enhancement mediated by α7 nicotinic acetylcholine receptors. Br.J.Pharmacol. 158 1486 PMID: 19845675

Ween et al (2010) α3* and α7 nAChR-mediated Ca2+ transient generation in IMR-32 neuroblastoma cells. Neurochem.Int. 57 269 PMID: 20558224

If you know of a relevant reference for NS 6784 hydrochloride, please let us know.

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