NS 6784 hydrochloride
α7 nAChR agonist at human and rat receptors (EC50 of 0.72 and 0.88 μM respectively). Stimulates α7 nAChR induced ERK phosphorylation in vitro and enhances avoidance learning in mice. Also evokes Ca2+ transients in IMR-32 neuroblastoma cells, with similar potency to PNU 282987 (Cat.No.2303).
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 306.79. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.26 mL||16.3 mL||32.6 mL|
|5 mM||0.65 mL||3.26 mL||6.52 mL|
|10 mM||0.33 mL||1.63 mL||3.26 mL|
|50 mM||0.07 mL||0.33 mL||0.65 mL|
References are publications that support the biological activity of the product.
Kouhen et al (2009) Pharmacology of α7 nicotinic acetylcholine receptor mediated extracellular signal-regulatedkinase signalling in PC12 cells. Br.J.Pharmacol. 156 638 PMID: 19226255
Briggs et al (2009) Role of channel activation in cognitive enhancement mediated by α7 nicotinic acetylcholine receptors. Br.J.Pharmacol. 158 1486 PMID: 19845675
Ween et al (2010) α3* and α7 nAChR-mediated Ca2+ transient generation in IMR-32 neuroblastoma cells. Neurochem.Int. 57 269 PMID: 20558224
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
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Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.
Learning & Memory Poster
Recognition memory enables us to make judgements about whether or not we have encountered a particular stimulus before. This poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression, as well as the use of pharmacological intervention to assess the role of neurotransmitters in recognition memory.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.