PNU 282987

Pricing Availability Delivery Time Qty
Cat.No. 2303 - PNU 282987 | C14H17ClN2O | CAS No. 123464-89-1
Description: Selective α7 nAChR agonist
Chemical Name: N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Highly selective α7 nAChR agonist (Ki = 26 nM) displaying negligible blockade of α1β1γδ and α3β4 nAChRs (IC50 ≥ 60 μM). Found to be inactive against a panel of 32 receptors at 1 μM, except 5-HT3 receptors (Ki = 930 nM).

Compound Libraries

PNU 282987 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 264.75
Formula C14H17ClN2O
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 123464-89-1
PubChem ID 9795278
InChI Key WECKJONDRAUFDD-ZDUSSCGKSA-N
Smiles O=C(C2=CC=C(Cl)C=C2)N[C@@H]1C3CCN(CC3)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 26.48 100
DMSO 26.48 100

Preparing Stock Solutions

The following data is based on the product molecular weight 264.75. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.78 mL 18.89 mL 37.77 mL
5 mM 0.76 mL 3.78 mL 7.55 mL
10 mM 0.38 mL 1.89 mL 3.78 mL
50 mM 0.08 mL 0.38 mL 0.76 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Bodnar et al (2005) Discovery and structure-activity relationship of quinuclidine benzamides as agonists of α7 nicotinic acetylcholine receptors. J.Med.Chem. 48 905 PMID: 15715459

Hajós et al (2005) The selective α7 nicotinic acetylcholine receptor agonist PNU-282987 [N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide hydrochloride] enhances GABAergic synaptic activity in brain slices and restores auditory gating deficits in anesthe J.Pharmacol.Exp.Ther. 312 1213 PMID: 15523001


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View Related Products by Product Action

View all Nicotinic (α7) Receptor Agonists

Keywords: PNU 282987, supplier, Selective, α7, alpha7, a7, nAChR, agonists, Nicotinic, Receptors, Acetylcholine, PNU282987, Nicotinic, (a7), Receptors, Nicotinic, (a7), Receptors, Tocris Bioscience

2 Citations for PNU 282987

Citations are publications that use Tocris products. Selected citations for PNU 282987 include:

Zhong et al (2013) Nicotine elicits prolonged calcium signaling along ventral hippocampal axons. Elife 8 e82719 PMID: 24349346

Wang et al (2012) Reducing amyloid-related Alzheimer's disease pathogenesis by a small molecule targeting filamin A. J Neurosci 32 9773 PMID: 22815492


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