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NQDI 1

Cat. No. 4429 1 Citation Submit a Review Datasheet / COA / SDS
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Cat.No. 4429 - NQDI 1 | C19H13NO4 | CAS No. 175026-96-7
Description: ASK1 inhibitor
Chemical Name: 2,7-Dihydro-2,7-dioxo-3H-naphtho[1,2,3-de]quinoline-1-carboxylic acid ethyl ester
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1, MAP3K5) (IC50 = 3 μM, Ki = 500 nM).

Technical Data

M. Wt 319.31
Formula C19H13NO4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 175026-96-7
PubChem ID 5522952
InChI Key UFJGFNHRMPMALC-UHFFFAOYSA-N
Smiles O=C2NC1=CC=CC4=C1C(C3=CC=CC=C3C4=O)=C2C(OCC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 3.19 10

Preparing Stock Solutions

The following data is based on the product molecular weight 319.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 31.32 mL 156.59 mL 313.18 mL
0.5 mM 6.26 mL 31.32 mL 62.64 mL
1 mM 3.13 mL 15.66 mL 31.32 mL
5 mM 0.63 mL 3.13 mL 6.26 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

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References

References are publications that support the biological activity of the product.

Bu et al (2001) Synthesis and cytotoxic activity of 7-oxo-7H-dibenz[f,ij]isoquinoline and 7-oxo-7H-benzo[e]perimidine derivatives. J.Med.Chem. 44 2004 PMID: 11384245

Volynets et al (2011) Identification of 3H-naphtho[1,2,3-de]quinoline-2,7-diones as inhibitors of apoptosis signal-regulating kinase 1 (ASK1). J.Med.Chem. 54 2680 PMID: 21449566

If you know of a relevant reference for NQDI 1, please let us know.

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Keywords: NQDI 1, NQDI 1 supplier, NQDI1, Apoptosis, signal-regulating, kinase, ASK1, inhibitors, inhibits, MAP3K5, 4429, Tocris Bioscience

1 Citation for NQDI 1

Citations are publications that use Tocris products. Selected citations for NQDI 1 include:

Song and Lee (2015) ASK1 modulates the expression of microRNA Let7A in microglia under high glucose in vitro condition. Psychopharmacology (Berl) 9 198 PMID: 26041997

Do you know of a great paper that uses NQDI 1 from Tocris? Please let us know.

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Literature in this Area

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Programmed Cell Death

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.