NQDI 1

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Cat.No. 4429 - NQDI 1 | C19H13NO4 | CAS No. 175026-96-7
Description: ASK1 inhibitor
Chemical Name: 2,7-Dihydro-2,7-dioxo-3H-naphtho[1,2,3-de]quinoline-1-carboxylic acid ethyl ester
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1, MAP3K5) (IC50 = 3 μM, Ki = 500 nM).

Technical Data

M. Wt 319.31
Formula C19H13NO4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 175026-96-7
PubChem ID 5522952
InChI Key UFJGFNHRMPMALC-UHFFFAOYSA-N
Smiles O=C2NC1=CC=CC4=C1C(C3=CC=CC=C3C4=O)=C2C(OCC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 3.19 10

Preparing Stock Solutions

The following data is based on the product molecular weight 319.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.13 mL 15.66 mL 31.32 mL
5 mM 0.63 mL 3.13 mL 6.26 mL
10 mM 0.31 mL 1.57 mL 3.13 mL
50 mM 0.06 mL 0.31 mL 0.63 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Bu et al (2001) Synthesis and cytotoxic activity of 7-oxo-7H-dibenz[f,ij]isoquinoline and 7-oxo-7H-benzo[e]perimidine derivatives. J.Med.Chem. 44 2004 PMID: 11384245

Volynets et al (2011) Identification of 3H-naphtho[1,2,3-de]quinoline-2,7-diones as inhibitors of apoptosis signal-regulating kinase 1 (ASK1). J.Med.Chem. 54 2680 PMID: 21449566


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Keywords: NQDI 1, supplier, NQDI1, Apoptosis, signal-regulating, kinase, ASK1, inhibitors, inhibits, MAP3K5, ASK1, ASK1, Tocris Bioscience

1 Citation for NQDI 1

Citations are publications that use Tocris products. Selected citations for NQDI 1 include:

Song and Lee (2015) ASK1 modulates the expression of microRNA Let7A in microglia under high glucose in vitro condition. Psychopharmacology (Berl) 9 198 PMID: 26041997


Do you know of a great paper that uses NQDI 1 from Tocris? If so please let us know.

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