NQ 301

Discontinued Product

NQ 301 (Cat. No. 5724) has been withdrawn from sale for commercial reasons.
Cat.No. 5724 - NQ 301 | C18H12ClNO3 | CAS No. 130089-98-4
Description: Selective CD45 inhibitor
Chemical Name: 2-[(4-Acetylphenyl)amino]-3-chloro-1,4-naphthalenedione
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity for NQ 301

NQ 301 is a selective CD45 inhibitor (IC50 = 200 nM). Exhibits >200-fold selectivity for CD45 over six related protein tyrosine phosphatases. Increases phosphorylation of Lck in Jurkat cells and reduces T cell receptor signaling in acitvated splenocytes in vitro. Blocks inflammation in a delayed-type hypersensitivity model in vivo.

Technical Data for NQ 301

M. Wt 325.75
Formula C18H12ClNO3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 130089-98-4
PubChem ID 781109
InChI Key LSQZKIQSQHZVQS-UHFFFAOYSA-N
Smiles O=C1C(Cl)=C(NC2=CC=C(C(C)=O)C=C2)C(C3=CC=CC=C31)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for NQ 301

References are publications that support the biological activity of the product.

Perron et al (2014) Allosteric noncompetitive small molecule selective inhibitors of CD45 tyrosine phosphatase suppress T-cell receptor signals and inflammation in vivo. Mol.Pharmacol. 85 553 PMID: 24473749

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Citations for NQ 301

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Currently there are no citations for NQ 301.

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Literature in this Area

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