You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for NQ 301
NQ 301 is a selective CD45 inhibitor (IC50 = 200 nM). Exhibits >200-fold selectivity for CD45 over six related protein tyrosine phosphatases. Increases phosphorylation of Lck in Jurkat cells and reduces T cell receptor signaling in acitvated splenocytes in vitro. Blocks inflammation in a delayed-type hypersensitivity model in vivo.
Technical Data for NQ 301
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for NQ 301
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for NQ 301
The following data is based on the product molecular weight 325.75. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.07 mL||15.35 mL||30.7 mL|
|5 mM||0.61 mL||3.07 mL||6.14 mL|
|10 mM||0.31 mL||1.53 mL||3.07 mL|
|50 mM||0.06 mL||0.31 mL||0.61 mL|
References for NQ 301
References are publications that support the biological activity of the product.
Perron et al (2014) Allosteric noncompetitive small molecule selective inhibitors of CD45 tyrosine phosphatase suppress T-cell receptor signals and inflammation in vivo. Mol.Pharmacol. 85 553 PMID: 24473749
If you know of a relevant reference for NQ 301, please let us know.
View Related Products by Product Action
Keywords: NQ 301, NQ 301 supplier, NQ301, selective, CD45, protein, tyrosine, phosphatase, PTP, inhibitors, inhibits, potent, leukocyte, common, antigen, LCA, Protein, Tyrosine, Phosphatases, 5724, Tocris Bioscience
Citations for NQ 301
Citations are publications that use Tocris products.
Currently there are no citations for NQ 301. Do you know of a great paper that uses NQ 301 from Tocris? Please let us know.
Reviews for NQ 301
There are currently no reviews for this product. Be the first to review NQ 301 and earn rewards!
Have you used NQ 301?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.