NQ 301

Pricing Availability   Qty
Cat.No. 5724 - NQ 301 | C18H12ClNO3 | CAS No. 130089-98-4
Description: Selective CD45 inhibitor
Chemical Name: 2-[(4-Acetylphenyl)amino]-3-chloro-1,4-naphthalenedione
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Selective CD45 inhibitor (IC50 = 200 nM). Exhibits >200-fold selectivity for CD45 over six related protein tyrosine phosphatases. Increases phosphorylation of Lck in Jurkat cells and reduces T cell receptor signaling in acitvated splenocytes in vitro. Blocks inflammation in a delayed-type hypersensitivity model in vivo.

Technical Data

M. Wt 325.75
Formula C18H12ClNO3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 130089-98-4
PubChem ID 781109
InChI Key LSQZKIQSQHZVQS-UHFFFAOYSA-N
Smiles O=C1C(Cl)=C(NC2=CC=C(C(C)=O)C=C2)C(C3=CC=CC=C31)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.58 100

Preparing Stock Solutions

The following data is based on the product molecular weight 325.75. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.07 mL 15.35 mL 30.7 mL
5 mM 0.61 mL 3.07 mL 6.14 mL
10 mM 0.31 mL 1.53 mL 3.07 mL
50 mM 0.06 mL 0.31 mL 0.61 mL

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References

References are publications that support the biological activity of the product.

Perron et al (2014) Allosteric noncompetitive small molecule selective inhibitors of CD45 tyrosine phosphatase suppress T-cell receptor signals and inflammation in vivo. Mol.Pharmacol. 85 553 PMID: 24473749


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