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Biological Activity for Noscapine hydrochloride
Noscapine hydrochloride is an opioid alkaloid with several actions. Binds to tubulin, arrests cells in mitosis and induces apoptosis. Antagonist at bradykinin receptors (pA2 = 6.68), inhibits carbachol-stimulated phosphoinositol turnover and enhances forskolin-stimulated cAMP increases in CNS tissues. Modulates IKK activation, suppressing the NF-κB signaling pathway. Blocks proliferation of human leukemia and multiple myeloma cells. Exhibits anti-inflammatory activity.
Technical Data for Noscapine hydrochloride
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Noscapine hydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Noscapine hydrochloride
The following data is based on the product molecular weight 449.88. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||4.45 mL||22.23 mL||44.46 mL|
|2.5 mM||0.89 mL||4.45 mL||8.89 mL|
|5 mM||0.44 mL||2.22 mL||4.45 mL|
|25 mM||0.09 mL||0.44 mL||0.89 mL|
Product Datasheets for Noscapine hydrochloride
References for Noscapine hydrochloride
References are publications that support the biological activity of the product.
Landen et al (2002) Noscapine alters microtubule dynamics in living cells and inhibits the progression of melanoma. Cancer Res. 62 4109 PMID: 12124349
Mahmoudian and Mojaverian (2001) Effect of noscapine, the antitussive opioid alkaloid, on bradykinin-induced smooth muscle contraction in the isolated ileum of the guinea-pig. Acta Physiol.Hung. 88 231 PMID: 12162581
Mourey et al (1992) [3H]Noscapine binding sites in brain: relationship to indoleamines and the phosphoinositide and adenylyl cyclase messenger systems. Mol.Pharmacol. 42 619 PMID: 1331753
Sung et al (2010) Noscapine, a benzylisoquinoline alkaloid, sensitizes leukemic cells to chemotherapeutic agents and cytokines by modulating the NF-κB signaling pathway. Cancer Res. 70 3259 PMID: 20354190
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Keywords: Noscapine hydrochloride, Noscapine hydrochloride supplier, Bradykinin, antagonists, tubulin, inhibitors, inhibits, induces, apoptosis, B1, B2, Receptors, Tau, Microtubules, Mitosis, antitumor, activity, HCl, opioid, alkaloid, 1697, Tocris Bioscience
1 Citation for Noscapine hydrochloride
Citations are publications that use Tocris products. Selected citations for Noscapine hydrochloride include:
Rennekamp et al (2016) σ1 receptor ligands control a switch between passive and active threat responses. Nat Chem Biol 12 552 PMID: 27239788
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Literature in this Area
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