Noladin ether

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Cat.No. 1411 - Noladin ether | C23H40O3 | CAS No. 222723-55-9
Description: Endogenous agonist for CB1 and GPR55
Alternative Names: HU 310, 2-Arachidonyl glycerol ether
Chemical Name: 2-[(5Z,8Z,11Z,14Z)-Eicosatetraenyloxy]-1,3-propanediol
Datasheet
Citations (1)
Literature

Biological Activity

Endogenous agonist for the GPR55 and CB1 receptors (EC50 values are 10 and 37 nM respectively) that displays selectivity over CB2 receptors (Ki values are 21.2 nM and > 3mM at CB1 and CB2 respectively). Causes sedation, hypothermia, intestinal immobility and mild antinociception in vivo. Attenuates sensory neurotransmission in rat mesenteric arteries via GPR55.

Technical Data

M. Wt 364.57
Formula C23H40O3
Storage Desiccate at -20°C
CAS Number 222723-55-9
PubChem ID 6483057
InChI Key CUJUUWXZAQHCNC-DOFZRALJSA-N
Smiles CCCCC\C=C/C\C=C/C/C=C\C/C=C\CCCCOC(CO)CO

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 5mg/ml)

Preparing Stock Solutions

The following data is based on the product molecular weight 364.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.74 mL 13.71 mL 27.43 mL
5 mM 0.55 mL 2.74 mL 5.49 mL
10 mM 0.27 mL 1.37 mL 2.74 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Duncan et al (2004) Noladin ether, a putative endocannabinoid, attenuates sensory neurotransmission in the rat isolated mesenteric arterial bed via a non-CB1/CB2 Gi/o linked receptor. Br.J.Pharmacol. 142 509 PMID: 15148262

Hanus et al (2001) 2-Arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor. Proc.Natl.Acad.Sci.U.S.A. 98 3662 PMID: 11259648

Ryberg et al (2007) The orphan receptor GPR55 is a novel cannabinoid receptor. Br.J.Pharmacol. 152 1092 PMID: 17876302

Sugiura et al (1999) Evidence that the cannabinoid CB1 receptor is a 2-arachidonoylglycerol receptor. J.Biol.Chem. 274 2794 PMID: 9915812

Suhara et al (2000) Synthesis and biological activities of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, and its metabolically stable ether-linked analogues. Chem.Pharm.Bull. 48 903 PMID: 10923815


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Keywords: Noladin ether, supplier, Endogenous, agonists, GPR55, CB1, Cannabinoids, Receptors, HU310, cb1r, HU, 310, 2-Arachidonyl, glycerol, ether, CB1, Receptors, GPR55, CB1, Receptors, Tocris Bioscience

1 Citation for Noladin ether

Citations are publications that use Tocris products. Selected citations for Noladin ether include:

Ho and Randall (2007) Endothelium-dependent metabolism by endocannabinoid hydrolases and cyclooxygenases limits vasorelaxation to anandamide and 2-arachidonoylglycerol. PLoS One 150 641 PMID: 17245358


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