Orphan neuropeptide, flanking nociceptin in the precursor pronociceptin. Stimulates locomotion in mice, possibly through a novel specific receptor.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 2081.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.48 mL||2.4 mL||4.8 mL|
|5 mM||0.1 mL||0.48 mL||0.96 mL|
|10 mM||0.05 mL||0.24 mL||0.48 mL|
|50 mM||0.01 mL||0.05 mL||0.1 mL|
References are publications that support the products' biological activity.
Florin et al (1997) Orphan neuropeptide NocII, a putative pronociceptin maturation product, stimulates locomotion in mice. NeuroReport 8 705 PMID: 9106751
Florin et al (1999) Comparison of behavioural effects of NocII or NocIII, two related pronociceptin-derived peptides. Life Sci. 65 2727 PMID: 10622282
If you know of a relevant reference for NocII, please let us know.
Keywords: NocII, supplier, Orphan, neuropeptide, Nociceptin, Receptors, ORL1, OP4, NOP, Opioid, neuropeptides, NOP, Receptors, NOP, Receptors, Tocris Bioscience
2 Citations for NocII
Citations are publications that use Tocris products. Selected citations for NocII include:
Laudenbach et al (2001) Nociceptin/orphanin FQ exacerbates excitotoxic white-matter lesions in the murine neonatal brain. J Clin Invest 107 457 PMID: 11181645
Krokowski (2017) GADD34 function in protein trafficking promotes adaptation to hyperosmotic stress in human corneal cells. Cell Rep 21 2895 PMID: 29212034
Do you know of a great paper that uses NocII from Tocris? If so please let us know.
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