Orphan neuropeptide, flanking nociceptin in the precursor pronociceptin. Stimulates locomotion in mice, possibly through a novel specific receptor.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble in water|
References are publications that support the biological activity of the product.
Florin et al (1997) Orphan neuropeptide NocII, a putative pronociceptin maturation product, stimulates locomotion in mice. NeuroReport 8 705 PMID: 9106751
Florin et al (1999) Comparison of behavioural effects of NocII or NocIII, two related pronociceptin-derived peptides. Life Sci. 65 2727 PMID: 10622282
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Keywords: NocII, NocII supplier, Orphan, neuropeptide, Nociceptin, Receptors, ORL1, OP4, NOP, Opioid, neuropeptides, 1119, Tocris Bioscience
2 Citations for NocII
Citations are publications that use Tocris products. Selected citations for NocII include:
Laudenbach et al (2001) Nociceptin/orphanin FQ exacerbates excitotoxic white-matter lesions in the murine neonatal brain. J Clin Invest 107 457 PMID: 11181645
Krokowski (2017) GADD34 function in protein trafficking promotes adaptation to hyperosmotic stress in human corneal cells. Cell Rep 21 2895 PMID: 29212034
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.