NNC 05-2090 hydrochloride

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Cat.No. 2747 - NNC 05-2090 hydrochloride | C27H30N2O2.HCl | CAS No. 184845-18-9
Description: GABA uptake inhibitor; moderately BGT-1 selective
Chemical Name: 1-[3-(9H-Carbazol-9-yl)propyl]-4-(2-methoxyphenyl)-4-piperidinol hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

GABA uptake inhibitor that displays moderate selectivity for BGT-1 (mGAT-2) transporters (Ki values are 1.4, 15, 19 and 41 μM for hBGT-1, hGAT-3, hGAT-1 and hGAT-2 respectively). Anticonvulsive; inhibits sound-induced tonic and clonic convulsions in DBA/2 mice. Also displays affinity at α1- and D2-receptors (IC50 values are 266 and 1632 nM respectively).

Compound Libraries

NNC 05-2090 hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 451.01
Formula C27H30N2O2.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 184845-18-9
PubChem ID 18782760
InChI Key WDFXPKKFSNMGOO-UHFFFAOYSA-N
Smiles Cl.COC1=C(C=CC=C1)C1(O)CCN(CCCN2C3=C(C=CC=C3)C3=C2C=CC=C3)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 45.1 100
ethanol 5.64 12.5

Preparing Stock Solutions

The following data is based on the product molecular weight 451.01. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.22 mL 11.09 mL 22.17 mL
5 mM 0.44 mL 2.22 mL 4.43 mL
10 mM 0.22 mL 1.11 mL 2.22 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Thomsen et al (1997) 1-(3-(9H-carbazol-9-yl)-1-propyl)-4-(2-methoxyphenyl)-4-piperidinol, a novel subtype selective inhibitor of the mouse type II GABA-transporter. Br.J.Pharmacol. 120 983 PMID: 9134205

Dalby et al (1997) Anticonvulsive properties of two GABA uptake inhibitors NNC 05-2045 and NNC 05-2090, not acting preferentially on GAT-1. Epilepsy Res. 28 51 PMID: 9255599


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1 Citation for NNC 05-2090 hydrochloride

Citations are publications that use Tocris products. Selected citations for NNC 05-2090 hydrochloride include:

Wang et al (2015) Neuronal γ-aminobutyric acid (GABA) type A receptors undergo cognate ligand chaperoning in the endoplasmic reticulum by endogenous GABA. Sleep 9 188 PMID: 26041994


Do you know of a great paper that uses NNC 05-2090 hydrochloride from Tocris? If so please let us know.

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