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Biological Activity for NK 252
NK 252 is a Nrf2 activator; interacts with the Nrf2-binding site of Keap1. Downregulates the expression of fibrogenic genes and increases antioxidant effects in NASH rat models of liver disease.
Compound Libraries for NK 252
Technical Data for NK 252
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for NK 252
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for NK 252
The following data is based on the product molecular weight 285.26. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.51 mL||17.53 mL||35.06 mL|
|5 mM||0.7 mL||3.51 mL||7.01 mL|
|10 mM||0.35 mL||1.75 mL||3.51 mL|
|50 mM||0.07 mL||0.35 mL||0.7 mL|
References for NK 252
References are publications that support the biological activity of the product.
Shimozono et al (2013) Nrf2 activators attenuate the progression of nonalcoholic steatohepatitis-related fibrosis in a dietary rat model. Mol.Pharmacol. 84 62 PMID: 23592516
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Keywords: NK 252, NK 252 supplier, NK252, NRF2, activators, activates, Keap1, Nrf2, 5293, Tocris Bioscience
Citations for NK 252
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Reviews for NK 252
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Literature in this Area
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