Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewNK 252
Description: Nrf2 activator
Chemical Name: N-[5-(2-Furanyl)-1,3,4-oxadiazol-2-yl]-N'-(2-pyridinylmethyl)urea
Purity: ≥98% (HPLC)
Biological Activity for NK 252
NK 252 is an Nrf2 activator; interacts with the Nrf2-binding site of Keap1. Downregulates the expression of fibrogenic genes and increases antioxidant effects in NASH rat models of liver disease.
Compound Libraries for NK 252
NK 252 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for NK 252
| M. Wt | 285.26 |
| Formula | C13H11N5O3 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1414963-82-8 |
| PubChem ID | 71618700 |
| InChI Key | FNSCFQXZZNCDAI-UHFFFAOYSA-N |
| Smiles | O=C(NC2=NN=C(C3=CC=CO3)O2)NCC1=CC=CC=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for NK 252
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 28.53 | 100 | |
| DMSO | 28.53 | 100 |
Preparing Stock Solutions for NK 252
The following data is based on the product molecular weight 285.26. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.51 mL | 17.53 mL | 35.06 mL |
| 5 mM | 0.7 mL | 3.51 mL | 7.01 mL |
| 10 mM | 0.35 mL | 1.75 mL | 3.51 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.7 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for NK 252
References for NK 252
References are publications that support the biological activity of the product.
Shimozono et al (2013) Nrf2 activators attenuate the progression of nonalcoholic steatohepatitis-related fibrosis in a dietary rat model. Mol.Pharmacol. 84 62 PMID: 23592516
If you know of a relevant reference for NK 252, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: NK 252, NK 252 supplier, NK252, NRF2, activators, activates, Keap1, Nrf2, 5293, Tocris Bioscience
1 Citation for NK 252
Citations are publications that use Tocris products. Selected citations for NK 252 include:
Vladimir et al (2021) A novel role of KEAP1/PGAM5 complex: ROS sensor for inducing mitophagy. Redox Biol 48 102186 PMID: 34801863
Do you know of a great paper that uses NK 252 from Tocris? Please let us know.
Reviews for NK 252
There are currently no reviews for this product. Be the first to review NK 252 and earn rewards!
Have you used NK 252?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cancer Metabolism Research Product Guide
This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including:
- Glycolysis
- Tricarboxylic Acid Cycle
- Lipidogenesis
- 1C Metabolism and Nucleic Acid Synthesis
- Drivers of Metabolic Reprogramming
- pH and Redox Balance
Cancer Metabolism Poster
This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.