NK 252

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Cat.No. 5293 - NK 252 | C13H11N5O3 | CAS No. 1414963-82-8
Description: Nrf2 activator
Chemical Name: N-[5-(2-Furanyl)-1,3,4-oxadiazol-2-yl]-N'-(2-pyridinylmethyl)urea
Purity: ≥98% (HPLC)
Datasheet
Citations
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Literature

Biological Activity

Nrf2 activator; interacts with the Nrf2-binding site of Keap1. Downregulates the expression of fibrogenic genes and increases antioxidant effects in NASH rat models of liver disease.

Compound Libraries

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Technical Data

M. Wt 285.26
Formula C13H11N5O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1414963-82-8
PubChem ID 71618700
InChI Key FNSCFQXZZNCDAI-UHFFFAOYSA-N
Smiles O=C(NC2=NN=C(C3=CC=CO3)O2)NCC1=CC=CC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 28.53 100
DMSO 28.53 100

Preparing Stock Solutions

The following data is based on the product molecular weight 285.26. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.51 mL 17.53 mL 35.06 mL
5 mM 0.7 mL 3.51 mL 7.01 mL
10 mM 0.35 mL 1.75 mL 3.51 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

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References

References are publications that support the biological activity of the product.

Shimozono et al (2013) Nrf2 activators attenuate the progression of nonalcoholic steatohepatitis-related fibrosis in a dietary rat model. Mol.Pharmacol. 84 62 PMID: 23592516


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Keywords: NK 252, NK 252 supplier, NK252, NRF2, activators, activates, Keap1, Nrf2, 5293, Tocris Bioscience

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