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NK 252

Cat. No. 5293 Submit a Review Datasheet / COA / SDS
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Description: Nrf2 activator
Chemical Name: N-[5-(2-Furanyl)-1,3,4-oxadiazol-2-yl]-N'-(2-pyridinylmethyl)urea
Purity: ≥98% (HPLC)
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for NK 252

NK 252 is an Nrf2 activator; interacts with the Nrf2-binding site of Keap1. Downregulates the expression of fibrogenic genes and increases antioxidant effects in NASH rat models of liver disease.

Compound Libraries for NK 252

NK 252 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for NK 252

M. Wt 285.26
Formula C13H11N5O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1414963-82-8
PubChem ID 71618700
InChI Key FNSCFQXZZNCDAI-UHFFFAOYSA-N
Smiles O=C(NC2=NN=C(C3=CC=CO3)O2)NCC1=CC=CC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NK 252

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 28.53 100
DMSO 28.53 100

Preparing Stock Solutions for NK 252

The following data is based on the product molecular weight 285.26. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.51 mL 17.53 mL 35.06 mL
5 mM 0.7 mL 3.51 mL 7.01 mL
10 mM 0.35 mL 1.75 mL 3.51 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

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References for NK 252

References are publications that support the biological activity of the product.

Shimozono et al (2013) Nrf2 activators attenuate the progression of nonalcoholic steatohepatitis-related fibrosis in a dietary rat model. Mol.Pharmacol. 84 62 PMID: 23592516

If you know of a relevant reference for NK 252, please let us know.

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Citations for NK 252

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