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Discontinued ProductNilvadipine (Cat. No. 5711) has been withdrawn from sale for commercial reasons.
Syk inhibitor. Blocks Aβ production, APPβ secretion and reduces BACE-1 expression in CHO cells over-expressing Aβ in vitro. Enhances clearance of Aβ across the blood brain barrier in vivo. Reduces brain Aβ levels in a mouse tauopathy model. Also L-type calcium channel blocker and antihypertensive.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Paris et al (2014) The spleen tyrosine kinase (Syk) regulates Alzheimer amyloid-β production and Tau hyperphosphorylation. J.Biol.Chem. 289 33927 PMID: 25331948
Cho et al (1989) Dihydropyrimidines: novel calcium antagonists with potent and long-lasting vasodilative and antihypertensive activity. J.Med.Chem. 32 2399 PMID: 2552119
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Keywords: Nilvadipine, Nilvadipine supplier, syk, inhibitors, inhibits, amyloid, beta, AB, Abeta, spleen, tyrosine, kinases, Alzheimer, disease, APP, precursor, protein, L-type, calcium, channel, blockers, Ca2+, β, Syk, Kinase, Cav1.x, Channels, 5711, Tocris Bioscience
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