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Cat.No. 5711 - Nilvadipine | C19H19N3O6 | CAS No. 75530-68-6
Description: Syk kinase inhibitor; inhibits Aβ production
Chemical Name: 2-Cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-(1-methylethyl) ester
Purity: ≥99% (HPLC)

Biological Activity

Syk inhibitor. Blocks Aβ production, APPβ secretion and reduces BACE-1 expression in CHO cells over-expressing Aβ in vitro. Enhances clearance of Aβ across the blood brain barrier in vivo. Reduces brain Aβ levels in a mouse tauopathy model. Also L-type calcium channel blocker and antihypertensive.

Technical Data

M. Wt 385.37
Formula C19H19N3O6
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 75530-68-6
PubChem ID 4494
Smiles O=C(OC)C1=C(C#N)NC(C)=C(C(OC(C)C)=O)C1C2=CC([N+]([O-])=O)=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 38.54 100
ethanol 19.27 50

Preparing Stock Solutions

The following data is based on the product molecular weight 385.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.59 mL 12.97 mL 25.95 mL
5 mM 0.52 mL 2.59 mL 5.19 mL
10 mM 0.26 mL 1.3 mL 2.59 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Paris et al (2014) The spleen tyrosine kinase (Syk) regulates Alzheimer amyloid-β production and Tau hyperphosphorylation. J.Biol.Chem. 289 33927 PMID: 25331948

Cho et al (1989) Dihydropyrimidines: novel calcium antagonists with potent and long-lasting vasodilative and antihypertensive activity. J.Med.Chem. 32 2399 PMID: 2552119

If you know of a relevant reference for Nilvadipine, please let us know.

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View all Syk Kinase Inhibitors

Keywords: Nilvadipine, supplier, syk, inhibitors, inhibits, amyloid, beta, AB, Abeta, spleen, tyrosine, kinases, Alzheimer, disease, APP, amyloid, precursor, protein, L-type, calcium, channel, blockers, Ca2+, β, Syk, Kinase, Voltage-gated, Calcium, Channels, Syk, Kinase, Tocris Bioscience

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