Discontinued Product

Nilvadipine (Cat. No. 5711) has been withdrawn from sale for commercial reasons.
Description: Syk kinase inhibitor; inhibits Aβ production
Chemical Name: 2-Cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-(1-methylethyl) ester
Purity: ≥99% (HPLC)

Biological Activity for Nilvadipine

Syk inhibitor. Blocks Aβ production, APPβ secretion and reduces BACE-1 expression in CHO cells over-expressing Aβ in vitro. Enhances clearance of Aβ across the blood brain barrier in vivo. Reduces brain Aβ levels in a mouse tauopathy model. Also L-type calcium channel blocker and antihypertensive.

Technical Data for Nilvadipine

M. Wt 385.37
Formula C19H19N3O6
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 75530-68-6
PubChem ID 4494
Smiles O=C(OC)C1=C(C#N)NC(C)=C(C(OC(C)C)=O)C1C2=CC([N+]([O-])=O)=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for Nilvadipine

References are publications that support the biological activity of the product.

Paris et al (2014) The spleen tyrosine kinase (Syk) regulates Alzheimer amyloid-β production and Tau hyperphosphorylation. J.Biol.Chem. 289 33927 PMID: 25331948

Cho et al (1989) Dihydropyrimidines: novel calcium antagonists with potent and long-lasting vasodilative and antihypertensive activity. J.Med.Chem. 32 2399 PMID: 2552119

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Citations for Nilvadipine

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