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Discontinued ProductNiflumic acid (Cat. No. 4112) has been withdrawn from sale for commercial reasons.
Biological Activity for Niflumic acid
Niflumic acid is a nonsteroidal anti-inflammatory drug (NSAID); selectively inhibits COX-2. Also activates human TRPA1 inducibly expressed in HEK293 cells; displays agonist activity at GPR35.
Technical Data for Niflumic acid
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References for Niflumic acid
References are publications that support the biological activity of the product.
Ottolia and Toro (1994) Potentiation of large conductance KCa channels by niflumic, flufenamic and mefenamic acids. Biophys.J. 67 2272 PMID: 7535111
Famaey (1997) In vitro and in vivo pharmacological evidence of selective cyclooxygenase-2 inhibition by nimesulide: an overview. Inflamm.Res. 46 437 PMID: 9427063
Hu et al (2010) Activation of TRPA1 channels by fenamate nonsteroidal anti-inflammatory drugs. Pflugers Arch. 459 579 PMID: 19888597
Deng et al (2012) Multiple tyrosine metabolites are GPR35 agonists. Sci.Rep. 2 373 PMID: 22523636
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Keywords: Niflumic acid, Niflumic acid supplier, cyclooxygenase, 2, cox-2, inhibitors, inhibits, Cyclooxygenase, GPR35, 4112, Tocris Bioscience
5 Citations for Niflumic acid
Citations are publications that use Tocris products. Selected citations for Niflumic acid include:
Xi et al (2020) Chloride intracellular channel 1 cooperates with potassium channel EAG2 to promote medulloblastoma growth. J Exp Med 217 PMID: 32097463
Rayner et al (2019) Mechanism and effects of pulsatile GABA secretion from cytosolic pools in the human beta cell. Nat Metab 1 1110-1126 PMID: 32432213
Cao et al (2014) SLC17A9 protein functions as a lysosomal ATP transporter and regulates cell viability. J Neuroinflammation 289 23189 PMID: 24962569
Amjad et al (2015) Conditional knockout of TMEM16A/anoctamin1 abolishes the calcium-activated chloride current in mouse vomeronasal sensory neurons. J Gen Physiol 145 285 PMID: 25779870
Ute et al (2022) Targeting the Hippo/YAP/TAZ signalling pathway: Novel opportunities for therapeutic interventions into skin cancers. Exp Dermatol 31 1477-1499 PMID: 35913427
Reviews for Niflumic acid
Average Rating: 5 (Based on 1 Review.)
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Non-selective cationic current was measured in guinea pig cardiomyocytes before and after superfusion with 100 µM niflumic acid for 10 min. Compared to time matched rundown, niflumic acid significantly increased inward as well as outward non-selective cationic current in cardiomyocytes.
Literature in this Area
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