Niflumic acid

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Cat.No. 4112 - Niflumic acid | C13H9F3N2O2 | CAS No. 4394-00-7
Description: Cyclooxygenase-2 (COX-2) inhibitor; GPR35 agonist
Chemical Name: 2-[3-(Trifluoromethyl)anilino]nicotinic acid
Datasheet
Citations (2)
Reviews (1)
Literature (7)

Biological Activity

Nonsteroidal anti-inflammatory drug (NSAID); selectively inhibits COX-2. Also activates human TRPA1 inducibly expressed in HEK293 cells; displays agonist activity at GPR35.

Technical Data

M. Wt 282.22
Formula C13H9F3N2O2
Storage Store at RT
CAS Number 4394-00-7
PubChem ID 4488
InChI Key JZFPYUNJRRFVQU-UHFFFAOYSA-N
Smiles O=C(C1=CC=CN=C1NC2=CC=CC(C(F)(F)F)=C2)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.22 100
ethanol 28.22 100

Preparing Stock Solutions

The following data is based on the product molecular weight 282.22. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.54 mL 17.72 mL 35.43 mL
5 mM 0.71 mL 3.54 mL 7.09 mL
10 mM 0.35 mL 1.77 mL 3.54 mL
50 mM 0.07 mL 0.35 mL 0.71 mL

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References

References are publications that support the biological activity of the product.

Ottolia and Toro (1994) Potentiation of large conductance KCa channels by niflumic, flufenamic and mefenamic acids. Biophys.J. 67 2272 PMID: 7535111

Famaey (1997) In vitro and in vivo pharmacological evidence of selective cyclooxygenase-2 inhibition by nimesulide: an overview. Inflamm.Res. 46 437 PMID: 9427063

Hu et al (2010) Activation of TRPA1 channels by fenamate nonsteroidal anti-inflammatory drugs. Pflugers Arch. 459 579 PMID: 19888597

Deng et al (2012) Multiple tyrosine metabolites are GPR35 agonists. Sci.Rep. 2 373 PMID: 22523636


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Keywords: Niflumic acid, Niflumic acid supplier, cyclooxygenase, 2, cox-2, inhibitors, inhibits, Cyclooxygenase, GPR35, 4112, Tocris Bioscience

2 Citations for Niflumic acid

Citations are publications that use Tocris products. Selected citations for Niflumic acid include:

Cao et al (2014) SLC17A9 protein functions as a lysosomal ATP transporter and regulates cell viability. J Neuroinflammation 289 23189 PMID: 24962569

Amjad et al (2015) Conditional knockout of TMEM16A/anoctamin1 abolishes the calcium-activated chloride current in mouse vomeronasal sensory neurons. J Gen Physiol 145 285 PMID: 25779870


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Niflumic acid increases non-selective cationic current in cardiomyocytes.
By Chintan Koyani on 10/23/2018
Assay Type: In Vitro
Species: Other
Cell Line/Tissue: Cardiomyocytes

Non-selective cationic current was measured in guinea pig cardiomyocytes before and after superfusion with 100 µM niflumic acid for 10 min. Compared to time matched rundown, niflumic acid significantly increased inward as well as outward non-selective cationic current in cardiomyocytes.

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