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Submit ReviewNiflumic acid
Description: Cyclooxygenase-2 (COX-2) inhibitor; GPR35 agonist
Chemical Name: 2-[3-(Trifluoromethyl)anilino]nicotinic acid
Biological Activity for Niflumic acid
Niflumic acid is a nonsteroidal anti-inflammatory drug (NSAID); selectively inhibits COX-2. Also activates human TRPA1 inducibly expressed in HEK293 cells; displays agonist activity at GPR35.
Technical Data for Niflumic acid
| M. Wt | 282.22 |
| Formula | C13H9F3N2O2 |
| Storage | Store at RT |
| CAS Number | 4394-00-7 |
| PubChem ID | 4488 |
| InChI Key | JZFPYUNJRRFVQU-UHFFFAOYSA-N |
| Smiles | O=C(C1=CC=CN=C1NC2=CC=CC(C(F)(F)F)=C2)O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Niflumic acid
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 28.22 | 100 | |
| ethanol | 28.22 | 100 |
Preparing Stock Solutions for Niflumic acid
The following data is based on the product molecular weight 282.22. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.54 mL | 17.72 mL | 35.43 mL |
| 5 mM | 0.71 mL | 3.54 mL | 7.09 mL |
| 10 mM | 0.35 mL | 1.77 mL | 3.54 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.71 mL |
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Product Datasheets for Niflumic acid
References for Niflumic acid
References are publications that support the biological activity of the product.
Ottolia and Toro (1994) Potentiation of large conductance KCa channels by niflumic, flufenamic and mefenamic acids. Biophys.J. 67 2272 PMID: 7535111
Famaey (1997) In vitro and in vivo pharmacological evidence of selective cyclooxygenase-2 inhibition by nimesulide: an overview. Inflamm.Res. 46 437 PMID: 9427063
Hu et al (2010) Activation of TRPA1 channels by fenamate nonsteroidal anti-inflammatory drugs. Pflugers Arch. 459 579 PMID: 19888597
Deng et al (2012) Multiple tyrosine metabolites are GPR35 agonists. Sci.Rep. 2 373 PMID: 22523636
If you know of a relevant reference for Niflumic acid, please let us know.
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Keywords: Niflumic acid, Niflumic acid supplier, cyclooxygenase, 2, cox-2, inhibitors, inhibits, Cyclooxygenase, GPR35, 4112, Tocris Bioscience
2 Citations for Niflumic acid
Citations are publications that use Tocris products. Selected citations for Niflumic acid include:
Amjad et al (2015) Conditional knockout of TMEM16A/anoctamin1 abolishes the calcium-activated chloride current in mouse vomeronasal sensory neurons. J Gen Physiol 145 285 PMID: 25779870
Cao et al (2014) SLC17A9 protein functions as a lysosomal ATP transporter and regulates cell viability. J Neuroinflammation 289 23189 PMID: 24962569
Do you know of a great paper that uses Niflumic acid from Tocris? Please let us know.
Reviews for Niflumic acid
Average Rating: 5 (Based on 1 Review.)
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Niflumic acid increases non-selective cationic current in cardiomyocytes.
By
Chintan Koyani on 10/23/2018
Assay Type: In Vitro
Species: Other
Cell Line/Tissue: Cardiomyocytes
Non-selective cationic current was measured in guinea pig cardiomyocytes before and after superfusion with 100 µM niflumic acid for 10 min. Compared to time matched rundown, niflumic acid significantly increased inward as well as outward non-selective cationic current in cardiomyocytes.
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