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Oligosaccharyltransferase (OST) inhibitor; anti-flaviviral. Inhibits dengue, Zika, West Nile, and yellow fever viruses by blocking viral RNA replication (EC50 values are 0.85 and 2.2 μM for DENV and ZIKV inhibition, respectively). Selectively arrests proliferation of non-small-cell lung cancer cells that are dependent on EGFR or FGFR for survival.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 394.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.53 mL||12.67 mL||25.35 mL|
|5 mM||0.51 mL||2.53 mL||5.07 mL|
|10 mM||0.25 mL||1.27 mL||2.53 mL|
|50 mM||0.05 mL||0.25 mL||0.51 mL|
References are publications that support the biological activity of the product.
Puschnik et al (2017) A small molecule oligosaccharyltransferase inhibitor with pan-flaviviral activity. Cell Rep. 21 3032 PMID: 29241533
Lopez-Sambrooks et al (2018) Oligosaccharyltransferase inhibition overcomes therapeutic resistance to EGFR tyrosine kinase inhibitors. Cancer Res. 78 5094 PMID: 30026325
Lopez-Sambrooks et al (2016) Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells. Nat.Chem.Biol. 12 1023 PMID: 27694802
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Keywords: NGI 1, NGI 1 supplier, NGI1, Oligosaccharyltransferases, OST, inhibitors, inhibits, antiflaviviral, dengue, Zika, West, Nile, yellow, fever, viruses, blocks, viral, RNA, replication, Other, Transferases, Flaviviruses, 6652, Tocris Bioscience
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