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Description: Oligosaccharyltransferase (OST) inhibitor; anti-flaviviral
Chemical Name: 5-[(Dimethylamino)sulfonyl]-N-(5-methyl-2-thiazolyl)-2-(1-pyrrolidinyl)benzamide
Purity: ≥98% (HPLC)

Biological Activity for NGI 1

NGI 1 is an oligosaccharyltransferase (OST) inhibitor; anti-flaviviral. Inhibits dengue, Zika, West Nile, and yellow fever viruses by blocking viral RNA replication (EC50 values are 0.85 and 2.2 μM for DENV and ZIKV inhibition, respectively). Selectively arrests proliferation of non-small-cell lung cancer cells that are dependent on EGFR or FGFR for survival.

Compound Libraries for NGI 1

NGI 1 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for NGI 1

M. Wt 394.51
Formula C17H22N4O3S2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 790702-57-7
PubChem ID 2519269
Smiles CN(S(=O)(C1=CC(C(NC2=NC=C(S2)C)=O)=C(N3CCCC3)C=C1)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NGI 1

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 39.45 100

Preparing Stock Solutions for NGI 1

The following data is based on the product molecular weight 394.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.53 mL 12.67 mL 25.35 mL
5 mM 0.51 mL 2.53 mL 5.07 mL
10 mM 0.25 mL 1.27 mL 2.53 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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References for NGI 1

References are publications that support the biological activity of the product.

Puschnik et al (2017) A small molecule oligosaccharyltransferase inhibitor with pan-flaviviral activity. Cell Rep. 21 3032 PMID: 29241533

Lopez-Sambrooks et al (2018) Oligosaccharyltransferase inhibition overcomes therapeutic resistance to EGFR tyrosine kinase inhibitors. Cancer Res. 78 5094 PMID: 30026325

Lopez-Sambrooks et al (2016) Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells. Nat.Chem.Biol. 12 1023 PMID: 27694802

If you know of a relevant reference for NGI 1, please let us know.

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Citations for NGI 1

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