NGI 1

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Cat.No. 6652 - NGI 1 | C17H22N4O3S2 | CAS No. 790702-57-7
Description: Oligosaccharyltransferase (OST) inhibitor; anti-flaviviral
Chemical Name: 5-[(Dimethylamino)sulfonyl]-N-(5-methyl-2-thiazolyl)-2-(1-pyrrolidinyl)benzamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Oligosaccharyltransferase (OST) inhibitor; anti-flaviviral. Inhibits dengue, Zika, West Nile, and yellow fever viruses by blocking viral RNA replication (EC50 values are 0.85 and 2.2 μM for DENV and ZIKV inhibition, respectively). Selectively arrests proliferation of non-small-cell lung cancer cells that are dependent on EGFR or FGFR for survival.

Technical Data

M. Wt 394.51
Formula C17H22N4O3S2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 790702-57-7
PubChem ID 2519269
InChI Key QPKGRLIYJGBKJL-UHFFFAOYSA-N
Smiles CN(S(=O)(C1=CC(C(NC2=NC=C(S2)C)=O)=C(N3CCCC3)C=C1)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.45 100

Preparing Stock Solutions

The following data is based on the product molecular weight 394.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.53 mL 12.67 mL 25.35 mL
5 mM 0.51 mL 2.53 mL 5.07 mL
10 mM 0.25 mL 1.27 mL 2.53 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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References

References are publications that support the biological activity of the product.

Puschnik et al (2017) A small molecule oligosaccharyltransferase inhibitor with pan-flaviviral activity. Cell Rep. 21 3032 PMID: 29241533

Lopez-Sambrooks et al (2018) Oligosaccharyltransferase inhibition overcomes therapeutic resistance to EGFR tyrosine kinase inhibitors. Cancer Res. 78 5094 PMID: 30026325

Lopez-Sambrooks et al (2016) Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells. Nat.Chem.Biol. 12 1023 PMID: 27694802


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Citations for NGI 1

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