NGD 94-1

Pricing Availability   Qty
Cat.No. 3298 - NGD 94-1 | C18H20N6 | CAS No. 178928-68-2
Description: Selective D4 receptor ligand
Chemical Name: 2-[4-[(2-Phenyl-1H-imidazol-5-yl)methyl]-1-piperazinyl]-pyrimidine
Purity: ≥99% (HPLC)
Literature (4)

Biological Activity

High affinity D4 receptor ligand; selective over D1, D2, D3 and D5 receptors. Displays antagonist activity at the human D4.2 receptor (Ki = 3.6 nM in transfected CHO cells) and exhibits agonist activity at the D4.4 receptor in HEK 293 cells.

Technical Data

M. Wt 320.39
Formula C18H20N6
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 178928-68-2
PubChem ID 188942
Smiles C1(N2CCN(CC3=CN=C(C4=CC=CC=C4)N3)CC2)=NC=CC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
1eq. HCl 32.04 100
DMSO 32.04 100

Preparing Stock Solutions

The following data is based on the product molecular weight 320.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.12 mL 15.61 mL 31.21 mL
5 mM 0.62 mL 3.12 mL 6.24 mL
10 mM 0.31 mL 1.56 mL 3.12 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

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References are publications that support the biological activity of the product.

Tallman et al (1997) I. NGD 94-1: Identification of a novel, high affinity antagonist at the human DA D4 receptor. J.Pharmacol.Exp.Ther. 282 1011 PMID: 9262370

Primus et al (1997) II. Localization and characterization of DA D4 binding sites in rat and human brain by use of the novel, D4 receptor-selective ligand [3H]NGD 94-1. J.Pharmacol.Exp.Ther. 282 1020 PMID: 9262371

Gazi et al (1999) NGD 94-1 as an agonist at human recombinant DA D4.4 receptors expressed in HEK293 cells. Eur.J.Pharmacol. 372 R9 PMID: 10395031

If you know of a relevant reference for NGD 94-1, please let us know.

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