NGD 94-1

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Cat.No. 3298 - NGD 94-1 | C18H20N6 | CAS No. 178928-68-2
Description: Selective D4 receptor ligand
Chemical Name: 2-[4-[(2-Phenyl-1H-imidazol-5-yl)methyl]-1-piperazinyl]-pyrimidine
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

High affinity D4 receptor ligand; selective over D1, D2, D3 and D5 receptors. Displays antagonist activity at the human D4.2 receptor (Ki = 3.6 nM in transfected CHO cells) and exhibits agonist activity at the D4.4 receptor in HEK 293 cells.

Technical Data

M. Wt 320.39
Formula C18H20N6
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 178928-68-2
PubChem ID 188942
InChI Key OTVQCHUIPJYASM-UHFFFAOYSA-N
Smiles C1(N2CCN(CC3=CN=C(C4=CC=CC=C4)N3)CC2)=NC=CC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 32.04 100
DMSO 32.04 100

Preparing Stock Solutions

The following data is based on the product molecular weight 320.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.12 mL 15.61 mL 31.21 mL
5 mM 0.62 mL 3.12 mL 6.24 mL
10 mM 0.31 mL 1.56 mL 3.12 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Tallman et al (1997) I. NGD 94-1: Identification of a novel, high affinity antagonist at the human dopamine D4 receptor. J.Pharmacol.Exp.Ther. 282 1011 PMID: 9262370

Primus et al (1997) II. Localization and characterization of dopamine D4 binding sites in rat and human brain by use of the novel, D4 receptor-selective ligand [3H]NGD 94-1. J.Pharmacol.Exp.Ther. 282 1020 PMID: 9262371

Gazi et al (1999) NGD 94-1 as an agonist at human recombinant dopamine D4.4 receptors expressed in HEK293 cells. Eur.J.Pharmacol. 372 R9 PMID: 10395031


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