NGD 94-1

Discontinued Product

NGD 94-1 (Cat. No. 3298) has been withdrawn from sale for commercial reasons.
Cat.No. 3298 - NGD 94-1 | C18H20N6 | CAS No. 178928-68-2
Description: Selective D4 receptor ligand
Chemical Name: 2-[4-[(2-Phenyl-1H-imidazol-5-yl)methyl]-1-piperazinyl]-pyrimidine
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (4)

Biological Activity for NGD 94-1

High affinity D4 receptor ligand; selective over D1, D2, D3 and D5 receptors. Displays antagonist activity at the human D4.2 receptor (Ki = 3.6 nM in transfected CHO cells) and exhibits agonist activity at the D4.4 receptor in HEK 293 cells.

Technical Data for NGD 94-1

M. Wt 320.39
Formula C18H20N6
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 178928-68-2
PubChem ID 188942
InChI Key OTVQCHUIPJYASM-UHFFFAOYSA-N
Smiles C1(N2CCN(CC3=CN=C(C4=CC=CC=C4)N3)CC2)=NC=CC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for NGD 94-1

References are publications that support the biological activity of the product.

Tallman et al (1997) I. NGD 94-1: Identification of a novel, high affinity antagonist at the human DA D4 receptor. J.Pharmacol.Exp.Ther. 282 1011 PMID: 9262370

Primus et al (1997) II. Localization and characterization of DA D4 binding sites in rat and human brain by use of the novel, D4 receptor-selective ligand [3H]NGD 94-1. J.Pharmacol.Exp.Ther. 282 1020 PMID: 9262371

Gazi et al (1999) NGD 94-1 as an agonist at human recombinant DA D4.4 receptors expressed in HEK293 cells. Eur.J.Pharmacol. 372 R9 PMID: 10395031

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Keywords: NGD 94-1, NGD 94-1 supplier, NGD941, antagonist, dopamine, receptors, D4, D4.2, dopaminergic, ligand, receptor, Receptors, 3298, Tocris Bioscience

Citations for NGD 94-1

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Currently there are no citations for NGD 94-1.

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