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Cat.No. 3656 - Neurodazine | C27H21ClN2O3 | CAS No. 937807-66-4
Description: Induces neurogenesis in mature skeletal muscle cells
Chemical Name: 2-[5-(3-Chlorophenyl)-2-furanyl]-4,5-bis(4-methoxyphenyl)-1H-imidazole
Purity: ≥99% (HPLC)
Literature (3)

Biological Activity

Induces neurogenesis of non-pluripotent C2C12 myoblasts and cells derived from mature human skeletal muscle. Upregulates the expression of neuron-specific markers in C2C12 cells.

Compound Libraries

Neurodazine is also offered as part of the Tocriscreen Stem Cell Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 456.92
Formula C27H21ClN2O3
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 937807-66-4
PubChem ID 16112820
Smiles ClC1=CC=CC(C(O3)=CC=C3C2=NC(C5=CC=C(OC)C=C5)=C(C4=CC=C(OC)C=C4)N2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 45.69 100
ethanol 22.85 50

Preparing Stock Solutions

The following data is based on the product molecular weight 456.92. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.19 mL 10.94 mL 21.89 mL
5 mM 0.44 mL 2.19 mL 4.38 mL
10 mM 0.22 mL 1.09 mL 2.19 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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References are publications that support the biological activity of the product.

Williams et al (2007) Synthetic small molecules that induce neurogenesis in skeletal muscle. J.Am.Chem.Soc. 129 9258 PMID: 17622149

Halder et al (2015) Combining suppression of stemness with lineage-specific induction leads to conversion of pluripotent cells into functional neurons. Chem.Biol. 22 1512 PMID: 26590637

If you know of a relevant reference for Neurodazine, please let us know.

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Keywords: Neurodazine, Neurodazine supplier, Neurodazine, stem, cells, neurogenesis, mature, human, skeletal, muscle, C2C12, myoblasts, neurogenics, Stem, Cell, Reprogramming, 3656, Tocris Bioscience

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Stem Cells

Stem Cells Scientific Review

Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

Stem Cell Workflow

Stem Cell Workflow Poster

Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.

Stem Cells

Stem Cells Poster

Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.