Neurodazine

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Cat.No. 3656 - Neurodazine | C27H21ClN2O3 | CAS No. 937807-66-4
Description: Induces neurogenesis in mature skeletal muscle cells
Chemical Name: 2-[5-(3-Chlorophenyl)-2-furanyl]-4,5-bis(4-methoxyphenyl)-1H-imidazole
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Induces neurogenesis of non-pluripotent C2C12 myoblasts and cells derived from mature human skeletal muscle. Upregulates the expression of neuron-specific markers in C2C12 cells.

Compound Libraries

Neurodazine is also offered as part of the Tocriscreen Plus and Tocriscreen Stem Cell Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 456.92
Formula C27H21ClN2O3
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 937807-66-4
PubChem ID 16112820
InChI Key FEEOFPAEDSMOTO-UHFFFAOYSA-N
Smiles ClC1=CC=CC(C(O3)=CC=C3C2=NC(C5=CC=C(OC)C=C5)=C(C4=CC=C(OC)C=C4)N2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 45.69 100
ethanol 22.85 50

Preparing Stock Solutions

The following data is based on the product molecular weight 456.92. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.19 mL 10.94 mL 21.89 mL
5 mM 0.44 mL 2.19 mL 4.38 mL
10 mM 0.22 mL 1.09 mL 2.19 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Williams et al (2007) Synthetic small molecules that induce neurogenesis in skeletal muscle. J.Am.Chem.Soc. 129 9258 PMID: 17622149

Halder et al (2015) Combining suppression of stemness with lineage-specific induction leads to conversion of pluripotent cells into functional neurons. Chem.Biol. 22 1512 PMID: 26590637


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Keywords: Neurodazine, supplier, Neurodazine, stem, cells, neurogenesis, mature, human, skeletal, muscle, cells, C2C12, myoblasts, neurogenics, Reprogramming, Tocris Bioscience

Citations for Neurodazine

Citations are publications that use Tocris products.

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Literature in this Area

Stem Cells

Stem Cells Scientific Review

Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

Pathways for Neurodazine

Protocols

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