Nefazodone hydrochloride

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Cat.No. 2777 - Nefazodone hydrochloride | C25H32ClN5O2.HCl | CAS No. 82752-99-6
Description: 5-HT2A antagonist; also 5-HT uptake inhibitor; antidepressant
Chemical Name: 2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one hydrochloride
Purity: ≥99% (HPLC)
Literature (6)

Biological Activity for Nefazodone hydrochloride

Nefazodone hydrochloride is a serotonin 5-HT2A receptor antagonist (Ki = 5.8 nM) and inhibitor of serotonin and noradrenalin uptake (IC50 values are 290 and 300 nM respectively). Displays no activity at 5-HT1B and 5-HT1D receptors. Active in models predictive of antidepressant potential.

Technical Data for Nefazodone hydrochloride

M. Wt 506.47
Formula C25H32ClN5O2.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 82752-99-6
PubChem ID 54911

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Nefazodone hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
1eq. HCl 5.06 10
DMSO 12.66 25

Preparing Stock Solutions for Nefazodone hydrochloride

The following data is based on the product molecular weight 506.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 7.9 mL 39.49 mL 78.98 mL
1.25 mM 1.58 mL 7.9 mL 15.8 mL
2.5 mM 0.79 mL 3.95 mL 7.9 mL
12.5 mM 0.16 mL 0.79 mL 1.58 mL

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Product Datasheets for Nefazodone hydrochloride

References for Nefazodone hydrochloride

References are publications that support the biological activity of the product.

Eison et al (1990) Nefazodone: preclinical pharmacology of a new antidepressant. Psychopharmacol.Bull. 26 311 PMID: 2274630

Davis et al (1997) Nefazodone. A review of its pharmacology and clinical efficacy in the management of major depression. Drugs 53 608 PMID: 9098663

Pullar et al (2000) LY367265, an inhibitor of the 5-hydroxytryptamine transporter and 5-hydroxytryptamine2A receptor antagonist: a comparison with the antidepressant, nefaz. Eur.J.Pharmacol. 407 39 PMID: 11050288

If you know of a relevant reference for Nefazodone hydrochloride, please let us know.

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Keywords: Nefazodone hydrochloride, Nefazodone hydrochloride supplier, 5-HT2A, antagonists, reuptake, inhibitors, inhibits, Antidepressant, Serotonin, Receptors, Transporters, SERT, 5-Hydroxytryptamine, Monoamine, Neurotransmitter, 5-HT, 2777, Tocris Bioscience

Citations for Nefazodone hydrochloride

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