Serotonin 5-HT2A receptor antagonist (Ki = 5.8 nM) and inhibitor of serotonin and noradrenalin uptake (IC50 values are 290 and 300 nM respectively). Displays no activity at 5-HT1B and 5-HT1D receptors. Active in models predictive of antidepressant potential.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 506.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.97 mL||9.87 mL||19.74 mL|
|5 mM||0.39 mL||1.97 mL||3.95 mL|
|10 mM||0.2 mL||0.99 mL||1.97 mL|
|50 mM||0.04 mL||0.2 mL||0.39 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Eison et al (1990) Nefazodone: preclinical pharmacology of a new antidepressant. Psychopharmacol.Bull. 26 311 PMID: 2274630
Davis et al (1997) Nefazodone. A review of its pharmacology and clinical efficacy in the management of major depression. Drugs 53 608 PMID: 9098663
Pullar et al (2000) LY367265, an inhibitor of the 5-hydroxytryptamine transporter and 5-hydroxytryptamine2A receptor antagonist: a comparison with the antidepressant, nefazodone. Eur.J.Pharmacol. 407 39 PMID: 11050288
If you know of a relevant reference for Nefazodone hydrochloride, please let us know.
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Keywords: 5-HT2A antagonists reuptake inhibitors inhibits Antidepressant Serotonin Receptors Transporters SERT 5-Hydroxytryptamine Monoamine Neurotransmitter 5-HT2A Receptors
Citations for Nefazodone hydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for Nefazodone hydrochloride. Do you know of a great paper that uses Nefazodone hydrochloride from Tocris? If so please let us know.
Literature in this Area
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
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