NCX 466
Biological Activity
Cyclooxygenase (COX)-inhibiting nitric oxide (NO) donor (CINOD). Inhibits COX-1 and COX-2 while releasing NO. Demonstrates higher efficacy than naproxen, its congener drug, in reducing levels of profibrotic cytokine transforming growth factor-β and oxidative stress in a mouse model of bleomycin-induced lung fibrosis. Orally available.
Technical Data
| M. Wt | 436.41 |
| Formula | C20H24N2O9 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1262956-64-8 |
| PubChem ID | 49855334 |
| InChI Key | QTUSNUCZIUBIBF-LIRRHRJNSA-N |
| Smiles | O=C(OCCCC[C@H](O[N+]([O-])=O)CO[N+]([O-])=O)[C@@H](C)C2=CC1=CC=C(OC)C=C1C=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.64 | 100 | |
| ethanol | 43.64 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 436.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.29 mL | 11.46 mL | 22.91 mL |
| 5 mM | 0.46 mL | 2.29 mL | 4.58 mL |
| 10 mM | 0.23 mL | 1.15 mL | 2.29 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
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References
References are publications that support the biological activity of the product.
Pini et al (2012) Prevention of bleomycin-induced lung fibrosis in mice by a novel approach of parallel inhibition of cyclooxygenase and nitric-oxide donation using NCX 466, a prototype cyclooxygenase inhibitor and nitric-oxide donor. J.Pharmacol.Exp.Ther. 341 493 PMID: 22344408
If you know of a relevant reference for NCX 466, please let us know.
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Keywords: NCX 466, NCX 466 supplier, NCX466, Cyclooxygenases, COX, COX1, COX2, COX-1, COX-2, inhibitors, inhibits, nitric, oxide, NO, donor, CINOD, inflammation, anti-inflammatory, profibrotic, Donors, /, Precursors, Cyclooxygenase, 4537, Tocris Bioscience
Citations for NCX 466
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Currently there are no citations for NCX 466. Do you know of a great paper that uses NCX 466 from Tocris? Please let us know.
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