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Mixed opioid receptor agonist/antagonist. Acts as a potent and full agonist at κ, a partial agonist at μ and δ opioid receptors (pEC50 values are 9.45, 8.74 and 8.61 in a cAMP assay, 9.70, 8.59 and 8.49 in a [35S]GTPγS binding assay respectively). Fails to exert agonist effects at NOP receptors and antagonizes agonist-induced NOP activation. Stimulates κ-, μ- and δ-mediated analgesia and blocks NOP-induced supraspinal nociception.
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 445.52. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||4.49 mL||22.45 mL||44.89 mL|
|2.5 mM||0.9 mL||4.49 mL||8.98 mL|
|5 mM||0.45 mL||2.24 mL||4.49 mL|
|25 mM||0.09 mL||0.45 mL||0.9 mL|
References are publications that support the biological activity of the product.
Connor and Kitchen (2006) Has the sun set on κ3-opioid receptors? Br.J.Pharmacol 147 349 PMID: 16402044
Gistrak et al (1989) Pharmacological actions of a novel mixed opiate agonist/antagonist: naloxone benzoylhydrazone J.Pharmacol.Exp.Ther. 251 469 PMID: 2553921
Olianas et al (2006) Agonist activity of naloxone benzoylhydrazone at recombinant and native opioid receptors. Br.J.Pharmacol. 147 360 PMID: 16402046
If you know of a relevant reference for Naloxone benzoylhydrazone, please let us know.
Keywords: Naloxone benzoylhydrazone, Naloxone benzoylhydrazone supplier, κ-opioid, kappa-opioid, agonists, partial, μ-opioid, mu-opioid, δ-opioid, delta-opioid, antagonists, NOP, Opioids, Receptors, NalBzOH, Miscellaneous/Non-selective, 1419, Tocris Bioscience
Citations for Naloxone benzoylhydrazone
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.