Naloxone benzoylhydrazone

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Cat.No. 1419 - Naloxone benzoylhydrazone | C26H27N3O4 | CAS No. 119630-94-3
Description: Full κ agonist, partial μ and δ agonist and antagonizes agonist-induced activation of NOP
Alternative Names: NalBzOH
Chemical Name: [(5α)-4,5-Epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-ylidene] benzoic acid hydrazide
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (5)

Biological Activity

Mixed opioid receptor agonist/antagonist. Acts as a potent and full agonist at κ, a partial agonist at μ and δ opioid receptors (pEC50 values are 9.45, 8.74 and 8.61 in a cAMP assay, 9.70, 8.59 and 8.49 in a [35S]GTPγS binding assay respectively). Fails to exert agonist effects at NOP receptors and antagonizes agonist-induced NOP activation. Stimulates κ-, μ- and δ-mediated analgesia and blocks NOP-induced supraspinal nociception.

Technical Data

M. Wt 445.52
Formula C26H27N3O4
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 119630-94-3
PubChem ID 9601084
InChI Key AKXCFAYOTIEFOH-XTNAHFASSA-N
Smiles O[C@@]23[C@@]([C@]5([H])/C(CC3)=N/NC(C6=CC=CC=C6)=O)(CC4)C1=C(O5)C(O)=CC=C1C[C@H]2N4CC=C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 22.28 50

Preparing Stock Solutions

The following data is based on the product molecular weight 445.52. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.49 mL 22.45 mL 44.89 mL
2.5 mM 0.9 mL 4.49 mL 8.98 mL
5 mM 0.45 mL 2.24 mL 4.49 mL
25 mM 0.09 mL 0.45 mL 0.9 mL

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References

References are publications that support the biological activity of the product.

Connor and Kitchen (2006) Has the sun set on κ3-opioid receptors? Br.J.Pharmacol 147 349 PMID: 16402044

Gistrak et al (1989) Pharmacological actions of a novel mixed opiate agonist/antagonist: naloxone benzoylhydrazone J.Pharmacol.Exp.Ther. 251 469 PMID: 2553921

Olianas et al (2006) Agonist activity of naloxone benzoylhydrazone at recombinant and native opioid receptors. Br.J.Pharmacol. 147 360 PMID: 16402046


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Keywords: Naloxone benzoylhydrazone, Naloxone benzoylhydrazone supplier, κ-opioid, kappa-opioid, agonists, partial, μ-opioid, mu-opioid, δ-opioid, delta-opioid, antagonists, NOP, Opioids, Receptors, NalBzOH, Miscellaneous/Non-selective, 1419, Tocris Bioscience

Citations for Naloxone benzoylhydrazone

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