Discontinued Product

NADA (Cat. No. 1568) has been withdrawn from sale for commercial reasons.
Description: Endogenous CB1 agonist; also vanilloid agonist and inhibitor of FAAH and AMT
Alternative Names: N-Arachidonyldopamine,AA-DA
Chemical Name: N-[2-(3,4-Dihydroxyphenyl)ethyl]-5Z,8Z,11Z,14Z-eicosatetraenamide
Citations (2)
Literature (2)

Biological Activity for NADA

NADA is a potent endogenous cannabinoid and vanilloid receptor agonist, with no action at dopamine receptors. Selective for CB1 over CB2 receptors (Ki values are 0.25 and 12 μM respectively), and potent agonist at TRPV1 (VR1) receptors (EC50 ~ 50 nM). Metabolically stable and competitively inhibits FAAH and anandamide transport. Has cannabinoid and vanilloid actions in vivo.

Technical Data for NADA

M. Wt 439.64
Formula C28H41NO3
Storage Desiccate at -20°C
CAS Number 199875-69-9
PubChem ID 5282105

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for NADA

Certificate of Analysis / Product Datasheet
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Keywords: NADA, NADA supplier, Endogenous, CB1, agonists, vanilloid, inhibitors, inhibits, FAAH, AMT, TRPV1, cannabinoids, Receptors, Vanillioids, VR1, Channels, Transient, Receptor, Potential, cb1r, N-Arachidonyldopamine, AA-DA, TRPV, 1568, Tocris Bioscience

2 Citations for NADA

Citations are publications that use Tocris products. Selected citations for NADA include:

Kaszás et al (2012) Small molecule positive allosteric modulation of TRPV1 activation by vanilloids and acidic pH. PLoS One 340 152 PMID: 22005042

Pitcher et al (2007) Spinal NKCC1 blockade inhibits TRPV1-dependent referred allodynia. J Pharmacol Exp Ther 3 17 PMID: 17603899

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cannabinoid Receptor Ligands Scientific Review

Cannabinoid Receptor Ligands Scientific Review

Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.