NAD 299 hydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 3282 - NAD 299 hydrochloride | C18H23FN2O2.HCl | CAS No. 184674-99-5
Description: Selective, high affinity 5-HT1A antagonist
Chemical Name: (3R)-3-(Dicyclobutylamino)-8-fluoro-3,4-dihydro-2H-1-benzopyran-5-carboxamide hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective, high affinity 5-HT1A receptor antagonist (Ki = 0.6 nM in vitro). Enhances the action of selective 5-HT reuptake inhibitors and reverses citalopram-induced (Cat. No. 1427) inhibition of serotonergic cell firing.

Licensing Information

Sold for research purposes under agreement from AstraZeneca

Compound Libraries

NAD 299 hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 354.85
Formula C18H23FN2O2.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 184674-99-5
PubChem ID 90488823
InChI Key GSZJANKLCPHEEX-BTQNPOSSSA-N
Smiles FC1=C2C(C[C@@H](N(C4CCC4)C3CCC3)CO2)=C(C(N)=O)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.48 100
water 35.48 100

Preparing Stock Solutions

The following data is based on the product molecular weight 354.85. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.82 mL 14.09 mL 28.18 mL
5 mM 0.56 mL 2.82 mL 5.64 mL
10 mM 0.28 mL 1.41 mL 2.82 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the products' biological activity.

Larsson et al (1998) Differential regional antagonism of 8-OH-DPAT-induced decrease in serotonin synthesis by two 5-HT1A receptor antagonists. Eur.J.Pharmacol. 346 209 PMID: 9652362

Arborelius et al (1999) The 5-HT1A receptor antagonist robalzotan completely reverses citalopram-induced inhibition of serotonergic cell firing. Eur.J.Pharmacol. 382 133 PMID: 10528148

Johansson et al (1997) The pharmacological characterization of a novel selective 5-hydroxytryptamine-1A receptor antagonist, NAD-299. J.Pharamacol.Exp.Ther. 283 216 PMID:


If you know of a relevant reference for NAD 299 hydrochloride, please let us know.

View Related Products by Target

View Related Products by Product Action

View all 5-HT1A Receptor Antagonists

Keywords: NAD 299 hydrochloride, supplier, AstraZeneca, 5-HT1A, serotonin, 5-HT, receptor, antagonists, NAD299, 5-HT1A, Receptors, Tocris Bioscience

Citations for NAD 299 hydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for NAD 299 hydrochloride. Do you know of a great paper that uses NAD 299 hydrochloride from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Depression

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

Parkinson's

Parkinson's Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.

Pathways for NAD 299 hydrochloride

Protocols

TODO: Add Protocols