N-Desmethylclozapine

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Cat.No. 1007 - N-Desmethylclozapine | C17H17ClN4 | CAS No. 6104-71-8
Description: 5-HT2C antagonist
Alternative Names: Normethylclozapine, Norclozapine
Chemical Name: 8-Chloro-11-(1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Reviews
Literature

Biological Activity

A major metabolite of clozapine; a potent and selective 5-HT2C serotonin receptor antagonist.

Technical Data

M. Wt 312.8
Formula C17H17ClN4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 6104-71-8
PubChem ID 210172
InChI Key NIBOMXUDFLRHRV-UHFFFAOYSA-N
Smiles ClC1=CC=C2NC3=C(C=CC=C3)C(=NC2=C1)N1CCNCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 31.28 100
DMSO 31.28 100

Preparing Stock Solutions

The following data is based on the product molecular weight 312.8. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.2 mL 15.98 mL 31.97 mL
5 mM 0.64 mL 3.2 mL 6.39 mL
10 mM 0.32 mL 1.6 mL 3.2 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Fox and Brotchie (1996) Normethylclozapine potentiates the action of quinpirole in the 6-hydroxyDA lesioned rat. Eur.J.Pharmacol. 301 27 PMID: 8773443

Kuoppamäki et al (1993) Clozapine and methylclozapine are potent 5-HT1C receptor antagonists. Eur.J.Pharmacol. 245 179 PMID: 8387927

Wong et al (1996) Effects of cloz. metabolites and chronic cloz. treatment on rat brain GABAA receptors. Eur.J.Pharmacol. 314 319 PMID: 8957253


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Keywords: N-Desmethylclozapine, N-Desmethylclozapine supplier, 5-HT2C, antagonists, Serotonin, Receptors, Norclozapine, Normethylclozapine, 1007, Tocris Bioscience

3 Citations for N-Desmethylclozapine

Citations are publications that use Tocris products. Selected citations for N-Desmethylclozapine include:

Gregory et al (2010) Identification of orthosteric and allosteric site mutations in M2 muscarinic acetylcholine receptors that contribute to ligand-selective signaling bias. J Biol Chem 285 7459 PMID: 20051519

Sur et al (2003) N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-MthD.-aspartate receptor activity. Proc Natl Acad Sci U S A 100 13674 PMID: 14595031

Magliaro and Saldanha (2009) Clozapine protects PC-12 cells from death due to oxidative stress induced by hydrogen peroxide via a cell-type specific mechanism involving inhibition of extracellular signal-regulated kinase phosphorylation. Brain Res 1283 14 PMID: 19501068


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Literature in this Area

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