Myelin Basic Protein (87-99)

Pricing Availability Delivery Time Qty
Cat.No. 3399 - Myelin Basic Protein (87-99) | Val-His-Phe-Phe-Lys-Asn-Ile-Val-Thr-Pro-Arg-Thr-Pro | CAS No. 118506-26-6
Description: Major antigenic component implicated in the pathophysiology of multiple sclerosis
Datasheet
Citations
Literature

Biological Activity

Encephalitogenic peptide that induces T cell proliferation with Th1 polarization in the CNS. Major antigenic component implicated in the pathophysiology of multiple sclerosis.

Technical Data

M. Wt 1555.8
Formula C74H114N20O17
Sequence VHFFKNIVTPRTP
Storage Store at -20°C
CAS Number 118506-26-6
PubChem ID 25077562
InChI Key XSSZRUKIAIQNAZ-SAKFXWCOSA-N
Smiles [H]N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 2 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1555.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.64 mL 3.21 mL 6.43 mL
5 mM 0.13 mL 0.64 mL 1.29 mL
10 mM 0.06 mL 0.32 mL 0.64 mL
50 mM 0.01 mL 0.06 mL 0.13 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the products' biological activity.

Jones et al (1992) The synthetic 87-99 peptide of myelin basic protein is encelphalitogenic in Buffalo rats. J.Neuroimmunol. 37 203 PMID: 1373154

Deraos et al (2008) Citrullination of linear and cyclic altered peptide ligands from myelin basic protein (MBP87-99) epitope elicits a Th1 polarized response by T cells isolated from multiple sclerosis patients: Implications in triggering disease. J.Med.Chem. 51 7834 PMID: 19053745

Hofstetter et al (2005) Does the frequency and avidity spectrum of the neuroantigen-specific T cells in the blood mirror the autoimmune process in the central nervous system of mice undergoing experimental allergic encephalomyelitis? J.Immunol. 22 4598 PMID:


If you know of a relevant reference for Myelin Basic Protein (87-99), please let us know.

Keywords: antigenic component implicated pathophysiology multiple sclerosis Encephalitogenic peptide Neuronal Metabolism Neuronal Metabolism

Citations for Myelin Basic Protein (87-99)

Citations are publications that use Tocris products.

Currently there are no citations for Myelin Basic Protein (87-99). Do you know of a great paper that uses Myelin Basic Protein (87-99) from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

Pathways for Myelin Basic Protein (87-99)

Protocols

TODO: Add Protocols